Samuel Shelburne, III, MD, PhD

Samuel Shelburne, III, MD, PhD

Deputy Chair, Department of Infectious Diseases, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center
Associate Professor, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center


Samuel Shelburne, M.D., and his research team focus on understanding the molecular basis of bacterial infections in humans. The laboratory seeks to understand the interaction between basic metabolic processes and bacterial virulence from a pathogen standpoint, using group A streptococcus as a model organism.

In addition, the team investigates the molecular basis of viridans group streptococcal infections and antimicrobial resistance in streptococci. Finally, they seek to understand how host genetics, microbiome, and pathogen genetics contribute to susceptibility and infection outcomes in patients with malignancy.

Specific projects include understanding the contribution of catabolite control protein A to GAS virulence, unraveling the complex regulation of virulence by the two component regulatory system CovRS in GAS, using WGS to determine and further study the genetic differences between invasive and non-invasive GAS, determining the epidemiology and important virulence factors associated with GBS strains causing infections in adults, and the molecular characterization of VGS causing invasive disease in cancer patients in order to better classify the individual VGS species , the diseases they cause, and their propensity for antibiotic resistance.

Education & Training

  • A.B.
    History of Art, Princeton University
  • M.D.
    University of Texas Medical Branch, Galveston, TX
  • Residency
    Internal Medicine, Baylor College of Medicine
  • Fellowship
    Infectious Diseases, Baylor College of Medicine
  • M.S.
    Clinical Investigation, Baylor College of Medicine
  • Ph.D.
    Baylor College of Medicine