The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases

Career Opportunities

DEPARTMENT OF NANOMEDICINE AND BIOMEDICAL ENGINEERING
POSTDOCTORAL RESEARCHER POSITION

Position Description:  We are seeking one highly motivated postdoctoral researcher to join Dr. Vittorio Cristini (Professor) and Dr. Zhihui Wang (Associate Professor)’s research group in the Department of Nanomedicine and Biomedical Engineering. This appointment is expected to begin on July 1, 2016 (start date negotiable). The successful applicant will be working on highly interdisciplinary research projects in the fields of mathematical cancer modeling and translational cancer research.

Keywords: Postdoc, Houston, mathematical modeling, cancer research, systems biology, systems medicine, computational biology, bioinformatics

Qualifications:  A Ph.D. or equivalent degree in applied mathematics, physics, engineering, or related quantitative scientific discipline is required by the time the appointment begins. M.D. or M.D./Ph.D. candidates with advanced computational training are also encouraged to apply. Experience in cancer research is a plus.

The applicant should have expertise and experience in mathematical modeling, especially numerical computation and analysis, e.g., development of ODE and PDE solvers using C/C++, Fortran, and/or Matlab. A proven track record in peer-reviewed publications in related fields is expected. Qualified candidates should be highly self-motivated and possess the ability to work independently as well as in a multidisciplinary collaborative environment. Excellent interpersonal, organizational, and oral and written English communication skills are required.

The applicant will work closely with the team and our experimental and clinical collaborators at UTHealth, MD Anderson Cancer Center, Baylor College of Medicine, and other institutions here in Houston and across the country. The applicant will have the opportunity to work on advanced, challenging research projects, primarily on predictive multiscale modeling of cancer using hybrid or statistical approaches. If interested, the applicant can also lead or participate in relevant projects available in the lab, including (1) drug pharmacokinetics and pharmacodynamics (PKPD) models, (2) biophysical models for predicting drug response in local and metastatic cancers, and (3) patient-specific mathematical models using data obtained from standard-of-care diagnostic imaging (histology, CT, MRI).

Special Instructions:  Candidates are encouraged to apply by May 1, 2016. Applications will be reviewed until the position is filled.

  1. Cover letter
  2. Curriculum Vitae
  3. Research statement (1-page)
  4. Three reference letters (the application is complete only when all three letters have been submitted)
  5. Publications or copies of creative work (a maximum of 3), if applicable

UTHealth is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.

Contact Information:

Zhihui Wang, Ph.D.
Associate Professor
Department of Nanomedicine and Biomedical Engineering
McGovern Medical School, a part of UTHealth


1881 East Road, CABI Building, Room 3.SCR6.4680
Houston, Texas 77054
Tel: 713-486-5425
Fax: 713-796-9697
Email: Zhihui.Wang@uth.tmc.edu


CENTER FOR STEM CELL AND REGENERATIVE MEDICINE
POST DOCTORAL POSITION

A postdoctoral position is available in the laboratory of Dr. Radbod Darabi, at Center for Stem Cell and Regenerative Medicine in University of Texas Health Science Center at Houston. The project is focused on skeletal myogenic differentiation of ES/iPS cells and gene correction of patient cells to be applicable for muscle regeneration.

The areas of laboratory's interests include developmental biology of skeletal muscle progenitors, stem cell biology and regenerative medicine in general. Studies are performed on genetically modified cells or mouse models, and involve the cutting edge approaches, such as cell lineage tracing, gene editing and in vivo experiments.

Hard working fresh PhD graduates and junior postdocs (less than 3 yrs.) who look for a vigorous and dynamic program on stem cell biology are encouraged to apply.

Requirements

  1. PhD degree with experience in stem cell biology, molecular cloning, advanced cell culture, animal modeling and/or bioinformatics.
  2. Fresh PhD graduate or junior postdoc (less than 3 yrs.)
  3. Be able to meet in person for interview and provide a scientific presentation

Please send your cover letter outlining your research interests, curriculum vitae and names (with e-mails) of 3-4 references to Dr. Darabi at Radbod.darabi@uth.tmc.edu 

UTHealth is an EEO/AA employer. UTHealth does not discriminate on the basis of race, color, religion, gender, sexual orientation, national origin, disability, age or any other basis prohibited by law. EOE/M/D/F/V".


TEXAS THERAPEUTICS INSTITUTE

POSTDOCTORAL POSITION IN FUNGAL GENETICS AND STRAIN DEVELOPMENT

Job Information

The Microbial Natural Products group within the Institute of Molecular Medicine’s Texas Therapeutics Institute is supervised by Profs. Gerald Bills and Zhiqiang An. Our research is directed towards on the discovery and development of novel antimicrobial agents and their biosynthesis. We anticipate a two-year sponsored project to use genomic engineering to increase production of a fungal natural product in the native organism. We are soliciting highly motivated applicants for a postdoctoral research position in metabolic engineering of fungi for the economic production of the targeted natural product. Hands-on experience in the areas of fungal genetic manipulations, transformation, gene targeting, gene inactivation, PCR, RT-PCR, and microbial metabolism are essential. A strong background in bioinformatics of fungal genomes is highly desirable. Experience with HPLC-MS, fermentation, metabolomics or elucidation of biosynthetic pathways would be highly beneficial. Efforts will include growth optimization studies at laboratory scales. Applicant need to have obtained their Ph.D. to be eligible for the position. Interested individuals should send a cover letter, CV, and the names and contact information for three references. The successful applicant will be selected based on the quality and breadth of their previous research experience, publication record, and potential for scientific growth and development. Applications will be accepted until the position is filled. Completed application packages and questions should be emailed to Prof. Gerald Bills, gerald.f.bills@uth.tmc.edu.

 >>Click here for Dr. Bill's IMM faculty page and/or here for his Google Scholar page.

Houston is the most populous city in Texas and the fourth most populous city in the United States. It offers a diverse and stimulating living environment and world class transportation facilities. The University of Texas Health Science Center at Houston (UTHealth) is the most comprehensive academic health center in Texas. It educates and trains health professionals and biomedical scientists, conducts cutting edge biomedical, behavioral, and population research, and provides both primary and highly specialized medical, dental, and public health care expertise. The laboratory is located on the 6th floor of the M.D. Anderson Cancer Center’s South Campus Research Building 3, in a wing dedicated to UTHealth’s Institute of Molecular Medicine. Other facilities of the Institute of Molecular Medicine are located a short distance away in the Fayez S. Sarofim Research Building.

UTHealth is an EEO/AA employer. UTHealth does not discriminate on the basis of race, color, religion, gender, sexual orientation, national origin, disability, age or any other basis prohibited by law. EOE/M/D/F/V".


TEXAS THERAPEUTICS INSTITUTE

POSTDOCTORAL POSITION IN MICROBIAL NATURAL PRODUCT CHEMISTRY

Job Information

The Microbial Natural Products group within the Institute of Molecular Medicine’s Texas Therapeutics Institute is supervised by Profs. Gerald Bills and Zhiqiang An. Our research is directed towards on the discovery and development of novel antimicrobial agents and their biosynthesis. To achieve this goal, we are currently working on (1) biosynthetic pathways of antifungal natural products; and (2) discovery of new antifungal agents from fungi. We are soliciting highly motivated applicants for a postdoctoral research position in natural product chemistry. Hands-on experience in the areas of secondary metabolite purification (HPLC and other chromatography techniques) and structure determination (NMR and MS data interpretation) is essential. Experience in culturing microorganisms, antimicrobial assays, metabolomics or elucidation of biosynthetic pathways would be highly beneficial. Applicant need to have obtained their Ph.D. to be eligible for the position. Interested individuals should send a cover letter, CV, and the names and contact information for three references. The successful applicant will be selected based on the quality and breadth of their previous research experience, publication record, and potential for scientific growth and development. Applications will be accepted until the position is filled. Completed application packages and questions should be emailed to Prof. Gerald Bills, gerald.f.bills@uth.tmc.edu.

 >>Click here for Dr. Bill's IMM faculty page and/or here for his Google Scholar page.

Houston is the most populous city in Texas and the fourth most populous city in the United States. It offers a diverse and stimulating living environment and world class transportation facilities. The University of Texas Health Science Center at Houston (UTHealth) is the most comprehensive academic health center in Texas. It educates and trains health professionals and biomedical scientists, conducts cutting edge biomedical, behavioral, and population research, and provides both primary and highly specialized medical, dental, and public health care expertise. The laboratory is located on the 6th floor of the M.D. Anderson Cancer Center’s South Campus Research Building 3, in a wing dedicated to UTHealth’s Institute of Molecular Medicine. Other facilities of the Institute of Molecular Medicine are located a short distance away in the Fayez S. Sarofim Research Building.

UTHealth is an EEO/AA employer. UTHealth does not discriminate on the basis of race, color, religion, gender, sexual orientation, national origin, disability, age or any other basis prohibited by law. EOE/M/D/F/V".


CENTER FOR CARDIOVASCULAR GENETICS

BIOINFORMATICIAN POSITION

The Center for Cardiovascular Genetics at The Brown Foundation Institute of Molecular Medicine has an open position for a BioInformatician, as a staff scientist/research associate, with experience and expertise in bioinformatics analysis of molecular genetic and genomic data, including analysis of whole exome sequencing, RNA-Sequencing, DNA methylation, and ChIP-sequencing data. 

Interested candidates should email their CV with a brief description of their research experience to Ali.J.Marian@uth.tmc.edu

 >>Click here for Dr. Marian's IMM faculty page.

UTHealth is an EEO/AA employer. UTHealth does not discriminate on the basis of race, color, religion, gender, sexual orientation, national origin, disability, age or any other basis prohibited by law. EOE/M/D/F/V".


CENTER FOR CARDIOVASCULAR GENETICS
POST-DOCTORAL POSITION

One (1) Post-doctoral Research position is open at the Center for Cardiovascular Genetics. The Research program relates to molecular genetics and biology of hereditary cardiomyopathies. The program requires studies in cell culture and animal models and human biological specimen.

No minimum post-doc experience is required. However, those with experience in molecular genetics and biology, particularly in the Cardiovascular field, would be given top priority.

The successful applicant will work closely with the faculty at the Center.

The interested candidates should email their CV to  Ali.J.Marian@uth.tmc.edu

 >>Click here Dr. Marian's IMM faculty page.

UTHealth is an EEO/AA employer. UTHealth does not discriminate on the basis of race, color, religion, gender, sexual orientation, national origin, disability, age or any other basis prohibited by law. EOE/M/D/F/V".


TEXAS THERAPEUTICS INSTITUTE

POST-DOCTORAL POSITION (in tumor evasion of antibody immunity)

We are looking for a postdoctoral fellow with experience in tumor microenvironment, cancer biology, antibody engineering, and/or immunology to study the concept that tumor associated proteinases can cause an impairment of IgG function through a limited cleavage in the hinge domain and thereby compromise antibody mediated immunity against cancer. Supported by a grant from CPRIT, the postdoc will establish the prevalence of IgG cleavage in clinical tumor samples followed by defining an anti-hinge antibody approach to “rescue” the functional activity of cleaved anticancer antibodies in vitro and in vivo. Qualified individuals should possess

  • the ability to design experiments, interpret and track results, and utilize this information to enable hypothesis generation;
  • the ability to work in a multidisciplinary team environment with strong communication skills.
  • Applicants should submit a CV, a brief research statement with career goal, contact information and three references to: Dr. Zhiqiang An at Zhiqiang.An@uth.tmc.edu. Visit Dr. An's webpage for more information on his research program.  

>>Click here Dr. Zhiqiang An

The University of Texas is an EO/AA employer. M/F/D/V. This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.


TEXAS THERAPEUTICS INSTITUTE
POST-DOCTORAL POSITION (in antibody response to viral infection and vaccination and the development of antiviral antibody therapies)

We are looking for two postdoctoral fellows with experience in virology, antibody engineering, and/or immunology to study the humoral response to viral infection and vaccination. Working closely with Merck Research Laboratories which partially fund the project, the postdoc will play a key role in addressing critical biological questions which will results in the discovery and development of vaccines and antibody therapies with a focus on HCMV and flu. Qualified individuals should possess

  • The ability to design experiments, interpret and track results, and utilize this information to enable hypothesis generation;
  • The ability to work in a multidisciplinary team environment with strong communication skills. Applicants should submit a CV, a brief research statement with career goal,
  • Your contact information and three references to: Dr. Zhiqiang An at zhiqiang.an@uth.tmc.edu. Visit Dr. An's webpage for more information on his research program.  

>>Click here Dr. Zhiqiang An

The University of Texas is an EO/AA employer. M/F/D/V. This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.


CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST-DOCTORAL POSITION

A postdoctoral position is available in the Dr. Eckel-Mahan lab at the The Brown Foundation Institute of Molecular Medicine ("IMM") within the University of Texas Health Sciences Center in Houston ("UTHealth"). Postdoctoral candidates with extensive experience with metabolic characterization of mouse models and some background in molecular and cell biology is strongly preferred.  Central research interests of the lab include the role of the circadian clock in metabolically healthy and diseased states. The postdoctoral candidate will utilize genomic approaches to study tissue-specific clock response to zeitgebers and manipulations that produce phenotypes mimicking human metabolic disorders. Experimentation centered on understanding the molecular mechanisms underlying tissue-specific clock activity will rely on a myriad of biochemical and molecular techniques. The successful postdoctoral candidate will be part of a larger group of scientists at the Center for Metabolic and Degenerative Diseases (MDD) who use integrative approaches to study metabolic and degenerative disorders.

The City of Houston houses a large and thriving research environment at the Texas Medical Center, which is composed of MD Anderson Cancer Center, UTHealth Sciences Center,and Baylor College of Medicine, among numerous other internationally-recognized research and medical institutions, mostly within walking distance of the IMM.

For further information regarding the advertised position, please contact: Kristin.L.Mahan@uth.tmc.edu. Interested candidates should send a cover letter describing research interests, a resume/CV, and the names and contact information for three references.

The position is open until filled.

The University of Texas is an EO/AA employer. M/F/D/V. This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.


TEXAS THERAPEUTICS INSTITUTE
POST-DOCTORAL POSITION IN MEDICINAL CHEMISTRY & BIOCHEMISTRY

We are looking for a postdoctoral fellow with experience in medicinal chemistry and biochemistry. Our lab is focused on the development of novel antimicrobial agents and strategies to solve clinical problems caused by drug-resistant pathogens. To achieve this goal, we are currently working on (1) synthesis and evaluation of antibacterial chemical probes for identifying novel therapeutic targets; and (2) design, synthesis, and evaluation of non-traditional antibacterial agents that can circumvent development of drug resistance. This is a unique opportunity to work at the interface of chemistry and biology, which includes not only chemical synthesis and biochemical studies, but also cross-disciplinary collaboration with clinical researchers and pharmaceutical industries.

Applicants should be independent, highly motivated individuals with a strong medicinal chemistry and biochemistry background and excellent research qualifications. Successful candidates must hold a doctoral degree, have a good publication record, and demonstrate excellent communication and writing skills. Applicants should submit a compiled PDF file including (1) CV (2) a brief research statement with your career goal (3) a list of publication, and (4) contact information for two references to: Dr. Kyoji Tsuchikama, Kyoji.Tsuchikama@uth.tmc.edu. Please add “Postdoc Application” to the top of the subject of your e-mail.

The University of Texas is an EO/AA employer. M/F/D/V. This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.


CENTER FOR METABOLIC AND DEGENERATIVE DISEASES

POST-DOCTORAL POSITION 

A postdoctoral research position is open for a PhD. with expertise in (1) metabolic characterization of mouse models, and (2) molecular studies of adipose tissue biology and pathology. The project will focus on adipose tissue remodeling during obesity development.

Research focuses:

  • Hypoxia stimulated fibrosis and local inflammation in adipose tissue.
  • Mechanisms by which angiogenic factors stimulate white adipocytes “browning” during early stage of obesity development (healthy expansion).
  • The effects of antiangiogenic action by blocking VEGF-A and/or its receptors in the context of preexisting adipose tissue (unhealthy expansion).
  • Reversibility of adipose tissue fibrosis by MT1-MMP (MMP14) and novel anti-fibrotic therapies for the treatment and prevention of obesity and diabetes.
  • The mechanisms by which MT1-MMT exerts profound pathophysiological effects in preexisted unhealthy fat tissue.

Qualifications: We welcome applications from highly qualified and motivated early-career scientists of all countries who have received a PhD degree within the last three years or who will receive their PhD degree by the start of the recruitment. Previous experience with animal work will be a big plus.   

Please submit personal statement, CV, and three letters of references to:

kai.sun@uth.tmc.edu

Kai Sun, MD, PhD
Assistant Professor
Center For Metabolic and Degenerative Diseases
The Brown Foundation Institute of Molecular Medicine
University of Texas Health Science Center at Houston
1825 Pressler st., Houston, TX 77030
Office: 713-500-3190

Visit our webpage at  -  The Center for Metabolic and Degenerative Diseases 

The University of Texas is an EO/AA employer. M/F/D/V.  This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.


CENTER FOR CARDIOVASCULAR GENOMICS
POST-DOCTORAL POSITION

A PostDoc Position is available immediately at the University of Texas Health Science Center at Houston (http://ibp.med.uth.tmc.edu/) in the field of cardiovascular genomics.  Our lab is investigating the genetics and pathogenesis of arrythmogenic cardiomyopathy (AC), the leading cause of sudden cardiac death in young people.  The successful applicant will have experience in both experimental and computational biology.  They will be responsible for performing biochemistry, molecular biology, and cell biology experiments, as well as performing bioinformatic analysis of a range of data types (genome sequencing, RNA-seq, ChIP-seq) to dissect the molecular determinants of the disease.  This position will be jointly supervised by Drs. AJ Marian and Jeffrey Chang.

Qualifications

To join our group, we are looking for highly motivated individuals that have demonstrated scientific productivity, excellent communication skills, and the capacity to conduct independent research.  We are interested in applicants from a range of backgrounds that hold a Ph.D. in Cell Biology, Biochemistry, Genetics, Computer Science, Bioinformatics, or comparable experience.  A background in cardiovascular biology is a plus.  Salary will follow NIH and university guidelines.

To Apply

Please send a CV, a brief statement of research interests, and contact information for three references to Dr. Jeffrey Chang (jeffrey.t.chang@uth.tmc.edu).  IMPORTANT: please include the words "Cardiovascular Genomics Postdoc" in the subject line of the email.

The University of Texas is an EO/AA employer. M/F/D/V.  This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.


CENTER FOR STEM CELL AND REGENERATIVE MEDICINE
POST DOCTORAL RESEARCH ASSOCIATE 

Center of Stem Cell and Regenerative Medicine in the Brown Foundation Institute of Molecular Medicine at the University of Texas Health Science Center at Houston has a available post doctoral research position developing tissue engineering approaches for spinal cord and traumatic brain injury in collaboration with the Vivian L. Smith Department of Neurosurgery at University of Texas Health Science Center at Houston.  Qualified candidates should have a doctoral degree, strong background and good first-author publications in tissue engineering utilizing stem cells as the cell source. Synthetic matrix preparation and stem cell culture will be required in this position.  Prior experience in material synthesis or processing is desirable but not required. The post doctoral researchers are expected to have strong work ethic, high self-motivation, critical thinking abilities, and excellent organizational and communication skills.

For those interested, please send a CV, contact information of three references, and a brief research statement describing past achievements, skills and research interests to Dr. Laura Smith Callahan at email at: laura.a.smithcallahan@uth.tmc.edu


TEXAS THERAPEUTICS INSTITUTE

Positions for postdoctoral fellows to study novel molecular mechanisms of cancer metastasis are available in Dr. Wenliang Li’s lab at the Institute of Molecular Medicine (IMM) of UTHealth-Houston.

Metastasis is responsible for over 90% of cancer death but its mechanisms are still poorly understood. Research in Dr. Li’s lab is to identify and study novel regulators of cancer metastasis, cancer stem cell, epithelial-mesenchymal transition (EMT), and drug resistance through a unique combination of RNAi/cDNA screens, cancer genomics, molecular cell biology, mouse models and patient specimens. The goals of the research are to gain new knowledge of metastasis and to identify novel cancer drug targets for the development of better therapeutics.

Qualified candidates should have a doctoral degree, strong background and good first-author publications in cancer biology, molecular cell biology, or signal transduction. Prior experience in mouse xenograft models is desirable but not required. The postdoc fellows are expected to have strong work ethic, high self-motivation, critical thinking abilities, excellent organizational and communication skills.

For those interested, please send a CV, contact information of three references, and a brief research statement describing past achievements, skills and research interests to Dr. Wenliang Li at email at: wenliang.li@uth.tmc.edu.

Faculty Profile:
Dr. Wenliang Li

TEXAS THERAPEUTICS INSTITUTE at

UTHealth - Houston
The Brown Foundation Institute of Molecular Medicine
for the Preventative of Human Diseases

1825 Pressler Street
Houston, TX 77030

The University of Texas is an EO/AA employer. M/F/D/V.  This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.


TEXAS THERAPEUTIC INSTITUTE, IMM

The Texas Therapeutics Institute (TTI) at the Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, is at the forefront of translation research in identifying drug targets and discovering potential therapeutics for cancer treatment.  Our research is focused on understanding the function and signaling mechanisms of ligand-receptor systems that play fundamental roles in the control of growth, proliferation, and migration of cancer cells as well as the self-renewal and differentiation of cancer stem cells.  Our approach to drug discovery is to generate and validate antibodies against targets that are essential to cancer cell survival and then demonstrate robust efficacy in tumor models.  We are equipped with state-of-the-art facilities and instruments to carry out cutting edge research of in vitro and in vivo studies.  Our faculties are highly experienced and successful in drug discovery and development. 

Post-doctoral positions are available in the laboratories of Drs. Zhiqiang An and Qingyun (Jim) Liu at TTI to study mechanism of signaling transduction of ligand-receptors systems in cancer cells and obtain training in drug discovery and development.   Successful candidates must have received Ph.D. within 2 years in the field of cell biology, cancer biology, pharmacology, or biochemistry with first author publications in leading journals.  They must also have strong skills in molecular biology and tissue culture, and the intellect, creativity, and writing skills to pursue a successful research career in academia or industry.

Interested candidates should email CV and at least one letter of references to qingyun.liu@uth.tmc.edu or to zhiqiang.an@uth.tmc.edu.

FACULTY PROFILES 

Zhiqiang An, Ph.D
Qingyun (Jim) Liu, Ph.D.

TEXAS THERAPEUTICS INSTITUTE at
UTHealth - Houston
The Brown Foundation Institute of Molecular Medicine
for the Preventative of Human Diseases
1825 Pressler Street
Houston, TX 77030

The University of Texas is an EO/AA employer. M/F/D/V.  This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.