The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases

Career Opportunities

CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST-DOCTORAL POSITION

A postdoctoral position is available in the Dr. Eckel-Mahan lab at the The Brown Foundation Institute of Molecular Medicine ("IMM") within the University of Texas Health Sciences Center in Houston ("UTHealth"). Postdoctoral candidates with extensive experience with metabolic characterization of mouse models and some background in molecular and cell biology is strongly preferred.  Central research interests of the lab include the role of the circadian clock in metabolically healthy and diseased states. The postdoctoral candidate will utilize genomic approaches to study tissue-specific clock response to zeitgebers and manipulations that produce phenotypes mimicking human metabolic disorders. Experimentation centered on understanding the molecular mechanisms underlying tissue-specific clock activity will rely on a myriad of biochemical and molecular techniques. The successful postdoctoral candidate will be part of a larger group of scientists at the Center for Metabolic and Degenerative Diseases (MDD) who use integrative approaches to study metabolic and degenerative disorders.

The City of Houston houses a large and thriving research environment at the Texas Medical Center, which is composed of MD Anderson Cancer Center, UTHealth Sciences Center,and Baylor College of Medicine, among numerous other internationally-recognized research and medical institutions, mostly within walking distance of the IMM.

For further information regarding the advertised position, please contact: Kristin.L.Mahan@uth.tmc.edu. Interested candidates should send a cover letter describing research interests, a resume/CV, and the names and contact information for three references.

The position is open until filled.

The University of Texas is an EO/AA employer. M/F/D/V. This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.


TEXAS THERAPEUTICS INSTITUTE
POST-DOCTORAL POSITION IN MEDICINAL CHEMISTRY & BIOCHEMISTRY

We are looking for a postdoctoral fellow with experience in medicinal chemistry and biochemistry. Our lab is focused on the development of novel antimicrobial agents and strategies to solve clinical problems caused by drug-resistant pathogens. To achieve this goal, we are currently working on (1) synthesis and evaluation of antibacterial chemical probes for identifying novel therapeutic targets; and (2) design, synthesis, and evaluation of non-traditional antibacterial agents that can circumvent development of drug resistance. This is a unique opportunity to work at the interface of chemistry and biology, which includes not only chemical synthesis and biochemical studies, but also cross-disciplinary collaboration with clinical researchers and pharmaceutical industries.

Applicants should be independent, highly motivated individuals with a strong medicinal chemistry and biochemistry background and excellent research qualifications. Successful candidates must hold a doctoral degree, have a good publication record, and demonstrate excellent communication and writing skills. Applicants should submit a compiled PDF file including (1) CV (2) a brief research statement with your career goal (3) a list of publication, and (4) contact information for two references to: Dr. Kyoji Tsuchikama, Kyoji.Tsuchikama@uth.tmc.edu. Please add “Postdoc Application” to the top of the subject of your e-mail.

The University of Texas is an EO/AA employer. M/F/D/V. This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.


CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST-DOCTORAL POSITION IN MUSCLE BIOLOGY

This position primarily focuses on regulation of skeletal muscle regeneration and size by nuclear receptors. The selected post-doctoral fellow will have the opportunity to participate in muscle research using transgenic targeting of nuclear receptors in mouse models of muscle disease, and work in collaboration with other laboratories in the world-famous Texas Medical Center. Additional information on our research can be obtained at: Vihang A. Narkar, PhD.

The selected candidate will conduct experiments in:

  • Cultured muscle cells.
  • Immunohistological characterization of murine muscle.
  • Mouse models of muscle disease.
  • Exercise and functional testing in mice.
  • DNA/RNA extraction and QPCR analysis of gene expression.
  • Cloning and standard molecular biology.

This position requires:

  • A recent PhD (degree granted within last 3-4 years) with peer-reviewed publications.
  • Extensive experience and hands-on training in the area of skeletal muscle biology using some of the aforementioned approaches.
  • Skills such as multi-tasking, creativity, proven independence, methodical approach to experimental design, excellent written and oral communication skills, strong interpersonal skills.

Candidates meeting the above requirement should apply by email (Vihang.a.narkar@uth.tmc.edu) to Vihang Narkar, Ph.D., Brown Foundation Institute of Molecular Medicine, University of Texas Medical School in Houston, TX, 77030. Please include a cover letter briefly describing research interest and future goals, detailed CV, and 3-4 references. Also state “Application for position in muscle biology’ in subject area of the email.

Visit our webpage at - The Center for Metabolic and Degenerative Diseases

The University of Texas is an EO/AA employer. M/F/D/V. This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.


CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST-DOCTORAL POSITION IN MECHANISMS OF ANGIOGENESIS

This position primarily focuses on regulation of angiogenesis by nuclear receptors. The selected post-doctoral fellow will have opportunities to conduct angiogenesis research using molecular biology, cell lines and animal models of vascular diseases, and work in collaboration with other laboratories in the world-famous Texas Medical Center. Additional information on our research can be obtained at: Vihang A. Narkar, PhD.

The selected candidate will conduct experiments including:

  • Cell culture.
  • Developing lentiviral over-expression or knockdown systems.
  • Transfections/infections to prepare transient or stable cell lines.
  • Immunohistology
  • DNA/RNA extraction and QPCR analysis.
  • Cloning and molecular biology.
  • In vitro & in vivo models of angiogenesis.

This position requires:

  • A recent PhD (degree granted within last 3-4 years) with peer-reviewed publications.
  • Extensive experience and hands-on training in molecular biology, cell biology and animal models, preferably in the area of angiogenesis.
  • Skills such as multi-tasking, creativity, proven independence, methodical approach to experimental design, excellent written and oral communication skills, strong interpersonal skills.

Candidates meeting the above requirements should apply by email (Vihang.a.narkar@uth.tmc.edu) to Vihang Narkar, Ph.D., Brown Foundation Institute of Molecular Medicine, University of Texas Medical School in Houston, TX, 77030. Please include a cover letter briefly describing research interest and future goals, detailed CV, and 3-4 references. Also state “Application for position in angiogenesis’ in subject area of the email.

The University of Texas is an EO/AA employer. M/F/D/V.  This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.


CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST-DOCTORAL POSITION 

A postdoctoral research position is open for a PhD. with expertise in (1) metabolic characterization of mouse models, and (2) molecular studies of adipose tissue biology and pathology. The project will focus on adipose tissue remodeling during obesity development.

Research focuses:

  • Hypoxia stimulated fibrosis and local inflammation in adipose tissue.
  • Mechanisms by which angiogenic factors stimulate white adipocytes “browning” during early stage of obesity development (healthy expansion).
  • The effects of antiangiogenic action by blocking VEGF-A and/or its receptors in the context of preexisting adipose tissue (unhealthy expansion).
  • Reversibility of adipose tissue fibrosis by MT1-MMP (MMP14) and novel anti-fibrotic therapies for the treatment and prevention of obesity and diabetes.
  • The mechanisms by which MT1-MMT exerts profound pathophysiological effects in preexisted unhealthy fat tissue.

Qualifications: We welcome applications from highly qualified and motivated early-career scientists of all countries who have received a PhD degree within the last three years or who will receive their PhD degree by the start of the recruitment. Previous experience with animal work will be a big plus.   

Please submit personal statement, CV, and three letters of references to:

kai.sun@uth.tmc.edu

Kai Sun, MD, PhD
Assistant Professor
Center For Metabolic and Degenerative Diseases
The Brown Foundation Institute of Molecular Medicine
University of Texas Health Science Center at Houston
1825 Pressler st., Houston, TX 77030
Office: 713-500-3190

Visit our webpage at  -  The Center for Metabolic and Degenerative Diseases 

The University of Texas is an EO/AA employer. M/F/D/V.  This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.


CENTER FOR CARDIOVASCULAR GENOMICS
POST-DOCTORAL POSITION

A PostDoc Position is available immediately at the University of Texas Health Science Center at Houston (http://ibp.med.uth.tmc.edu/) in the field of cardiovascular genomics.  Our lab is investigating the genetics and pathogenesis of arrythmogenic cardiomyopathy (AC), the leading cause of sudden cardiac death in young people.  The successful applicant will have experience in both experimental and computational biology.  They will be responsible for performing biochemistry, molecular biology, and cell biology experiments, as well as performing bioinformatic analysis of a range of data types (genome sequencing, RNA-seq, ChIP-seq) to dissect the molecular determinants of the disease.  This position will be jointly supervised by Drs. AJ Marian and Jeffrey Chang.

Qualifications

To join our group, we are looking for highly motivated individuals that have demonstrated scientific productivity, excellent communication skills, and the capacity to conduct independent research.  We are interested in applicants from a range of backgrounds that hold a Ph.D. in Cell Biology, Biochemistry, Genetics, Computer Science, Bioinformatics, or comparable experience.  A background in cardiovascular biology is a plus.  Salary will follow NIH and university guidelines.

To Apply

Please send a CV, a brief statement of research interests, and contact information for three references to Dr. Jeffrey Chang (jeffrey.t.chang@uth.tmc.edu).  IMPORTANT: please include the words "Cardiovascular Genomics Postdoc" in the subject line of the email.

The University of Texas is an EO/AA employer. M/F/D/V.  This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.


CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST-DOCTORAL POSITION

A postdoctoral research position is open for a Ph.D. with expertise in (1) FACS primary cell separation and (2) high-throughput library screening. The project will focus on adipocyte progenitor cells.

Preference will be given to candidates with experience in one (or more) of the following:

  • metabolism / biochemistry / physiology
  • experimental therapeutics / pharmacology

Research in the laboratory converges on the biology of obesity and cancer with a specific focus on adipose stromal cells. 

Personal statement, CV, and letters of reference should be submitted to: mikhail.g.kolonin@uth.tmc.edu

Mikhail Kolonin, Ph.D.
Associate Professor
Director, Center For Metabolic and Degenerative Diseases
Annie and Bob Graham Distinguished Chair in Stem Cell Biology
The Brown Foundation Institute of Molecular Medicine
University of Texas Health Science Center at Houston
1825 Pressler st., Houston, TX 77030
Office: 713-500-3146

Visit our webpage at  -  The Center for Metabolic and Degenerative Diseases 

UTHealth is an Equal Opportunity Employer: M/F/D/V. This is a security sensitive position and thereby subject to TX Edu. Code Section 51.215. A background check will be required for the final candidate.


CENTER FOR STEM CELL AND REGENERATIVE MEDICINE
POST DOCTORAL RESEARCH ASSOCIATE 

Center of Stem Cell and Regenerative Medicine in the Brown Foundation Institute of Molecular Medicine at the University of Texas Health Science Center at Houston has a available post doctoral research position developing tissue engineering approaches for spinal cord and traumatic brain injury in collaboration with the Vivian L. Smith Department of Neurosurgery at University of Texas Health Science Center at Houston.  Qualified candidates should have a doctoral degree, strong background and good first-author publications in tissue engineering utilizing stem cells as the cell source. Synthetic matrix preparation and stem cell culture will be required in this position.  Prior experience in material synthesis or processing is desirable but not required. The post doctoral researchers are expected to have strong work ethic, high self-motivation, critical thinking abilities, and excellent organizational and communication skills.

For those interested, please send a CV, contact information of three references, and a brief research statement describing past achievements, skills and research interests to Dr. Laura Smith Callahan at email at: laura.a.smithcallahan@uth.tmc.edu.


TEXAS THERAPEUTICS INSTITUTE
ASSISTANT PROFESSOR POSITION

THE INSTITUTE OF MOLECULAR MEDICINE | University of Texas Medical School- Houston

The Brown Foundation Institute of Molecular Medicine (IMM) in the University of Texas Medical School at Houston is a translational research institute that investigates the cause of human diseases at the genetic, cellular and molecular level. We invite applications for a chemistry faculty position at the Texas Therapeutics Institute (TTI), one of eight research centers within the IMM.

The appointment will be at the Assistant Professor level on the tenure track. The candidate will be expected to develop an independently supported research program that applies synthetic and natural product organic chemistry techniques to design methods for the synthesis of therapeutic compounds, to solve lead molecule optimization problems, to prepare molecules with novel chemical or biological properties or to enhance structural diversity. There will be extensive opportunities for collaboration with IMM scientists working in diverse areas of biology. Some background in basic understanding of cancer biology, enzymology, pharmacology, pharmacokinetics, and molecular modeling would be beneficial. Applicants will have the opportunity of a joint appointment within the Department of Nanomedicine and Biomedical Engineering, or the Department of Integrative Biology and Pharmacology.

The IMM (http://www.uthouston.edu/imm/) has outstanding research facilities and is located within the Texas Medical Center, which includes UT-Health Sciences Center, Baylor College of Medicine and M.D. Anderson Cancer Center.  An attractive start-up package and competitive salary and benefits will be provided. 

To apply please fill-out application on-line @ https://jobs.uth.tmc.edu, requisition #130969. 

You will need to attach the following:

  • You will need to attach your Curriculum Vitae
  • A letter that addresses the position criteria
  • A brief description of future research plans
  • Contact details of three referees

Letters should be addressed to:   Dr. Zhiqiang An, Director of the Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Medical School at Houston 

Review of applications will begin immediately and will continue until the position is filled. The University of Texas is an Equal Opportunity Employer and encourages 


CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST DOCTORAL POSITION

Post-doctoral positions are available in the laboratory of Dr. Vihang Narkar at the Center for Metabolic and Degenerative Diseases, Institute of Molecular Medicine, University of Texas Medical School at Houston.  The successful candidate will use a combination of molecular biology, tissue culture, immuno-histochemistry and mouse genetic engineering to study transcriptional signaling in skeletal muscle-linked diseases such as diabetes and muscular dystrophy. Desirable candidates will have a recent Ph.D. in biological sciences, will be highly motivated and innovative, and have research expertise in transcriptional regulation and/or muscle physiology, as demonstrated by first-author paper(s) in peer-reviewed journals. 

Interested candidates should email a cover letter describing research goals, CV and a list of three references to (Please indicate POST-DOCTORAL APPLICANT in the email subject):

Vihang A. Narkar, Ph.D.

Assistant Professor
Center for Metabolic and Degenerative Diseases
Institute of Molecular Medicine
University of Texas Medical School at Houston

Email: vihang.a.narkar@uth.tmc.edu
Website:
http://www.uthouston.edu/imm/profile.htm?id=1402137 

UTHealth is an Equal Opportunity Employer: M/F/D/V. This is a security sensitive position and thereby subject to TX Edu. Code Section 51.215. A background check will be required for the final candidate.


TEXAS THERAPEUTIC INSTITUTE

Positions for postdoctoral fellows to study novel molecular mechanisms of cancer metastasis are available in Dr. Wenliang Li’s lab at the Institute of Molecular Medicine (IMM) of UTHealth-Houston.

Metastasis is responsible for over 90% of cancer death but its mechanisms are still poorly understood. Research in Dr. Li’s lab is to identify and study novel regulators of cancer metastasis, cancer stem cell, epithelial-mesenchymal transition (EMT), and drug resistance through a unique combination of RNAi/cDNA screens, cancer genomics, molecular cell biology, mouse models and patient specimens. The goals of the research are to gain new knowledge of metastasis and to identify novel cancer drug targets for the development of better therapeutics.

Qualified candidates should have a doctoral degree, strong background and good first-author publications in cancer biology, molecular cell biology, or signal transduction. Prior experience in mouse xenograft models is desirable but not required. The postdoc fellows are expected to have strong work ethic, high self-motivation, critical thinking abilities, excellent organizational and communication skills.

For those interested, please send a CV, contact information of three references, and a brief research statement describing past achievements, skills and research interests to Dr. Wenliang Li at email at: wenliang.li@uth.tmc.edu.

Faculty Profile:
Dr. Wenliang Li

TEXAS THERAPEUTICS INSTITUTE at

UTHealth - Houston
The Brown Foundation Institute of Molecular Medicine
for the Preventative of Human Diseases

1825 Pressler Street
Houston, TX 77030

The University of Texas is an EO/AA employer. M/F/D/V.  This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.


TEXAS THERAPEUTIC INSTITUTE, IMM

The Texas Therapeutics Institute (TTI) at the Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, is at the forefront of translation research in identifying drug targets and discovering potential therapeutics for cancer treatment.  Our research is focused on understanding the function and signaling mechanisms of ligand-receptor systems that play fundamental roles in the control of growth, proliferation, and migration of cancer cells as well as the self-renewal and differentiation of cancer stem cells.  Our approach to drug discovery is to generate and validate antibodies against targets that are essential to cancer cell survival and then demonstrate robust efficacy in tumor models.  We are equipped with state-of-the-art facilities and instruments to carry out cutting edge research of in vitro and in vivo studies.  Our faculties are highly experienced and successful in drug discovery and development. 

Post-doctoral positions are available in the laboratories of Drs. Zhiqiang An and Qingyun (Jim) Liu at TTI to study mechanism of signaling transduction of ligand-receptors systems in cancer cells and obtain training in drug discovery and development.   Successful candidates must have received Ph.D. within 2 years in the field of cell biology, cancer biology, pharmacology, or biochemistry with first author publications in leading journals.  They must also have strong skills in molecular biology and tissue culture, and the intellect, creativity, and writing skills to pursue a successful research career in academia or industry.

Interested candidates should email CV and at least one letter of references to qingyun.liu@uth.tmc.edu or to zhiqiang.an@uth.tmc.edu.

FACULTY PROFILES 

Zhiqiang An, Ph.D
Qingyun (Jim) Liu, Ph.D.

TEXAS THERAPEUTICS INSTITUTE at
UTHealth - Houston
The Brown Foundation Institute of Molecular Medicine
for the Preventative of Human Diseases
1825 Pressler Street
Houston, TX 77030

The University of Texas is an EO/AA employer. M/F/D/V.  This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.