Dr. David Volk, Ph.D.

Dr. David Volk, Ph.D.

Associate Professor, Center for Translational Cancer Research

Email Address: David.Volk@uth.tmc.edu
Phone Number: 713-500-3195
Room Number: SRB 330E


Fax 713.500.0319

Dr. Volk received his B.A. (Physics and Mathematics) from Minot State University and his Ph.D. (Chemistry) from North Dakota State University where his work focused on reaction mechanisms studied by low temperature NMR and quantum mechanics. His postdoctoral training at Duke University and UT Medical Branch focused on NMR-derived protein and DNA structure determinations. As a Research Scientist at UTMB, his work focused on structural biology, aptamers, NMR-based metabolomics/bioinformatics and quantum chemistry. He joined the IMM in 2009, in 2010 became an Assistant Professor in the Center for Proteomics and Systems Biology, and now is an Associate Professor in the Center for Precision Biomedicine.

Research Interests

Dr. Volk’s current research interests include using bioinformatics techniques applied to proteomic and metabolite studies of patient populations and in the development of novel classes of DNA thioaptamer libraries for use as therapeutic and diagnostic agents. Our recent work focuses on combining aptamers and nanoparticles.

David E Volk on My NCBI


(74) Amero, P., Lokesh, G.L.R., Chaudhari, R.R., Cardenas-Zuniga, R., Schubert, T., Attia, Y.M., Montalvo-Gonzalez, E., Elsayed, A.M., Ivan, C., Wang, Z., Cristini, V., de Franciscis, V., Zhang, S., Volk, D.E., Mitra, R., Rodriguez-Aguayo, C., Sood, A.K., and Lopez-Berestein, G., J. Am. Chem. Soc. 143, 20, 7655–7670, 2021.  https://doi.org/10.1021/jacs.9b10460

(73) Functional Blockade of E-selectin in Tumor-associated Vessels Enhances Anti-Tumor Effect of Doxorubicin in Breast Cancer. Morita, Y, Leslie, M, Kameyama, H, Lokesh, GLR, Ichimura, N,  Davis, R, Natalie Hills, N, Hasan, N, Zhang, R, Kondo, Y, Gorenstein, DG, Volk, DE,  Cheveroneva, I, Hallgeir, R, and Tanaka, T. , Cancers, 12, 725, 2020. 

(72) Kobayashi, H., Yue Yu, Y., and Volk D.E., “Thymosins”, Chapter 13 (pp 311-326) in Hormonal Signaling in Biology and Medicine: Comprehensive Modern Endocrinology, Gerald Litwack (Ed.), Oct. 23, 2019. Paperback ISBN: 9780128138144; eBook ISBN: 9780128138151. ©Academic Press 2020. 

(71) Tracking biodistribution of myeloid-derived cells in murine models of breast cancer. Li, J, Mai, J, Hinkle, L, Lin, D, Zhang, J, Liu, X, Ramirez, MR, Zu, Y, Lokesh, G, Volk, DE, Shen, H.  Genes (2019) 10:297. 

(70) Bioinformatics service center projects go beyond service. Chang, JT, Volk, DE, Gorenstein, DG, Steffen, D, and Bernstam, EV. J Biomedical Informatics (2019) 94: 103192. 

(69) X-Aptamer Technology Identifies C4A and ApoB in Blood as Potential Markers for SchizophreniaWalss-Bass, C., Lokesh, G.L.R., Dyukova, E., Gorenstein, D.G., Roberts, D.L., Velligan D., Volk, D.E.  Molecular Neuropsychiatry, (2019) 5:52–59. 

(68) A DNA thioaptamer with homing specificity to lymphoma bone marrow involvement. Mai, J., Li, X, Zhang, G., Huang, Y., Xu, R., Shen, Q., Lokesh, G., Thiviyanathan, V., Chen, L., Liu, H., Zu, Y., Ma, X., Volk, D., Gorenstein, D. G., Ferrari, M., Shen, H. Molecular Pharmaceutics 15(5), 1814-1825, 2018. DOI: 0.1021/acs.molpharmaceut.7b01169

(67) Aptamer Therapeutics in Cancer: Current and Future. Morita, Y., Leslie, M., Kameyama, H., Volk, D.E., and Tanaka, T.  Cancers 2018, 10(3), 80; doi:10.3390/cancers10030080

(66) A Novel DNA Aptamer for Dual Targeting of Polymorphonuclear Myeloid-derived Suppressor Cells and Tumor Cells. Liu, H., Mai, J., Shen, J., Wolfram, J., Li, Z., Zhang, G., Xu, R., Li, Y., Mu, C., Li, X., Lokesh, G.L., Thiviyanathan, V., Volk, D.E., Gorenstein, D.G., Ferrari, M., Hu, Z., Shen, H. Theranostics 2018, 8(1), 31-44; doi:10.7150/thno.21342

(65) Thioaptamer Targeted Discoidal Microparticles Increase Self Immunity and Reduce Mycobacterium Tuberculosis Burden in Mice. Leonard, F., Ha, N.P., Sule, P., Yuan, J., Alexander, J.F., Volk, D.E., Lokesh, G.L., Liu, X., Cirillo, J.D., Gorenstein, D.G., Chatterjee, S., Graviss, E.A., Biana Godin, B., Molecules 2017, 22, 1355; doi:10.1016/j.conrel.2017.09.038

(64) A unique and simple approach to improve sensitivity in 15N NMR relaxation measurements for NH3+ groups: Application to a protein-DNA complex. Nguyen, D., Lokesh, G.L.R., Volk, D.E., Iwahara, J., Molecules 2017, 22, 1355; doi:10.3390/molecules22081355

(63) Development of Phosphorothioate DNA and DNA ThioaptamersVolk*, D.E., Lokesh, G.L.R. Biomedicines 5(3), 41, 2017; doi:10.3390/biomedicines5030041

(62) Therapeutic Targeting of AXL Receptor Tyrosine Kinase Inhibits Tumor Growth and Intraperitoneal Metastasis in Ovarian Cancer Models. Kanlikilicer, P., Ozpolat, B., Aslan, B., Bayraktar, R., Gurbuz, N., Rodriguez-Aguayo, C., Bayraktar, E., Denizli, M., Gonzalez-Villasana, V., Ivan, C., Lokesh, G.L.R., Amero, P., Catuogno, V., Haemmerle, M., Wu, S.Y.-Y., RMitra, R., Gorenstein, D.G., Volk, D.E., de Franciscis, V., Sood, A.K., Lopez-Berestein, G. Molecular Therapy: Nucleic Acids, 9, 251-262, (2017); doi:10.1016/j.omtn.2017.06.023

(61) Chapter 10: X-Aptamer Selection and ValidationLokesh, G.L., Wang, H., Lam, C.H., Thiviyanathan, V., Ward, N., Gorenstein, D.G. and Volk, D.E. in RNA Nanostructures: Methods and Protocols, Eckart Bindewald and Bruce A. Shapiro (Eds), Methods in Molecular Biology, Volume 1632, pp 151-174, Elsevier, 2017; ISBN: 978-1-4939-7137-4

(60) E-selectin Targeting PEGylated-thioaptamer Prevents Breast Cancer Metastases. Morita, Y., Kamal, M., Kang, S.-A., Zhang, R., Lokesh, G., Thiviyanathan, V., Hasan, N., Woo, S., Zhao, D., Leslie, M., Suh, S., Razaq, W., Rui, H., Gorenstein, D.G., Volk, D.E., Tanaka, T. Molecular Therapy Nucleic Acids (2016) 5, e399 doi:10.1038/mtna.2016.103.

(59) Morph-X-Select: Morphology-based aptamer tissue selection for ovarian cancer biomarker discovery. Wang, H., Li, X., Volk, D.E., Lokesh, G.L.-R., Elizondo-Riojas, M.-A., Li, L., Nick, A.M., Anil K. Sood, A.K., Rosenblatt, K.P., Gorenstein, D.G. Biotechniques, 61:249-259, 2016.

(58) Improving vascular maturation using non-coding RNAs increases anti-tumor effect of chemotherapy. Mangala, L.S., Wang, H.,* Jian, D., Wu, S.Y., Somasunderam, A., Volk, D.E., Lokesh, G.L.R., Li, X., Pradeep, S., Yang, X., Haemmerle, M., Rodriguez-Aguayo, C., Nagaraja, A.S., Rupaimoole, R., Bayraktar, E., Bayratktar, R., Li, L., Tanaka, T., Hu, W., Ivan, C., Gharpure, K.M., McGuire, M.H., Thiviyanathan, V., Zhang, X., Maiti, S.N., Bulayeva, N., Choi, H.-J., Dorniak, P.L., Cooper, L.J.N., Rosenblatt, K.P., Lopez-Berestein, G., Gorenstein, D.G., Sood, A.K. Journal of Clinical Investigation - Insights, 2016;1(17):e87754. doi:10.1172/jci.insight.87754. PMC5070952

(57) Developing hyperpolarized silicon particles to be used for in vivo MRI targeting of ovarian cancer. Whiting, N., Hua, J., Millward, N.Z., Banksonc, J., Lokesh, G.L.R., Volk, D.E., Sood, A. K., Bhattacharya, P.  J. Med Imaging, 3(3), 036001, 2016doi:10.1117/1.JMI.3.3.036001 PMC4979585

(56) Structures of Thymosin Proteins, in Vitamins and Hormones: Thymosins, vol 102:1-24, Gerald Litwack, Ed. Hoch, K. and Volk, D.E., Academic Press 2016Abstract

(55) Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice. Kang, S., Tsolmon, B., Mann, A.P., Zheng, W., Zhao, L., Zhao, Y. D., Volk, D. E., Lokesh, G. L. R., Morris, L., Gupta, V., Morris, L., Rui, H., Suh, S., Gorenstein, D. G., Tanaka, T. Toxicol and Appl. Pharmacol., 287(1), 86-92, 2015PMC4966538 Free PDF

(54) Blocking the adhesion cascade at the premetastatic niche for prevention of breast cancer metastasis. Kang, S., Hasan, N., Mann, A. P., Zheng, W., Zhao, L., Morris, L., Zhu, W., Zhao, Y. D., Suh, K. S., Dooley, W. C., Volk, D., Gorenstein, D.G., Cristofanilli, M., Rui, H. and Tanaka, T. Molecular Therapy, 23(6), 1044-1054, 2015PMC4817749 Free PDF

(53) Acquisition of Data at Multiple Gains within Single Thermal Melt Experiment Using the RotorGeneQ Instrument. S H A Gandham, D E Volk, and D G Gorenstein  J. Anal. Sci. and Tech., Jan. 2015 Article online

(52) Thioaptamers targeting Dengue virus type-2 envelope protein domain III. S H A Gandham, D E Volk, L G L Rao, N. Neerathilingam and D G Gorenstein, Biochem Biophys Res Commun.   453(3):309-315, 2014. DOI:10.1016/j.bbrc.2014.09.053 PMC4272640 Free PDF

(51) Bone marrow endothelium-targeted therapeutics for metastatic breast cancer. J Mai, Y Huang, C Mu, G Zhang, R Xu, X Guo, X Xia, D E Volk, G L Lokesh, V Thiviyanathan, D G Gorenstein, X Liu, M Ferrari, H Shen J. Control Release 187, 22-29, 2014PMC4109393 Free PDF

(50) Aptaligner: Automated Software for Aligning Pseudo-Random DNA X-Aptamers from Next-Generation Sequencing Data. E. Lu, M.-A. Elizondo-Riojas, J. T. Chang and D. E. Volk. Biochemistry 53(22), 3523-3525, 2014PMC4059528 Free PDF

(49) X-Aptamers: A bead-based selection method for random incorporation of drug-like moieties onto next-generation aptamers for enhanced binding. Weiguo He, Miguel-Angel Elizondo-Riojas, Xin Li, Ganesh Lakshmana Rao Lokesh, Anoma Somasunderam, Varatharasa Thiviyanathan, David E. Volk, Ross H. Durland, Johnnie Englehardt, Claudio N. Cavasotto, David G. Gorenstein Biochemistry 51(42):8321-8323, 2012. PMC3924539 Free PDF

(48) Aggregation Behavior of Ibuprofen, cholic acid and dodecylphosphocholine micelles. P. Prakash, A. Sayyed-Ahmad, Y. Zhou, D. E. Volk, D. G. Gorenstein, E. Dial, L. M. Lichtenberger, A. A. Gorfe. BBA - Biomembranes 1818(12), 3040-3047, 2012PMC3478136 Free PDF

(47) Aptamers as attractive choices in diagnostic and therapeutic applications. V. Thiviyanathan, A. Somasunderam, D.E. Volk, J. Klostergaard, D.G. Gorenstein  Proc. Inst. Chem. Ceylon (Sri Lanka), 204-209, June 2012.

(46) 1H Nuclear Magnetic Resonance (NMR) Metabolomic Study of Chronic Organophosphate Exposure in Rats. Alam, T.*, Neerthilingam, M., Alam, K., Volk, D., Sarkar, S., Ansari, S., and Luxon, B.  Metabolites2(3):479-495, 2012. Free PDF

(45) NMR Structural studies of thymosin alpha-1 and b-thymosins. Volk, D. E., Tuthill, C.W., Elizondo-Riojas, M.-A. and Gorenstein, D.G. Ann. N.Y. Acad. Sci. 1270:73-78, 2012Journal Abstract

(44) Insight into NSAID-induced membrane alterations, pathogenesis and therapeutics: characterization of interaction of NSAIDs with phosphatidylcholine. L M Lichtenberger, V Jayaraman, J R Doyen, R G O Neil, E J Dial, Y Yong Zhou, D E Volk, D G Gorenstein, U Marathi, M B Boggara, R Krishnamoorti  Biochim. et Biophys. Acta (BBA) - Molecular and Cell Biology of Lipids , 1821(7): 994-1002, 2012.

(43) NMR Structure of Human Thymosin Alpha-1. Elizondo-Riojas, M.-A., Chamow, S.M., Tuthill, C.W., Gorenstein, D.G., Volk, D.E. Biochem. Biophys. Res. Commun. , 416:356-361, 2011PMC3419375 (Free PDF)

(42) Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting. A.P. Mann, R.C. Bhavane, A. Somasunderam, B.L. Montalvo-Ortiz, K.B. Ghaghada, D. Volk, R. Nieves-Alicea, K.S. Suh, M. Ferrari, A. Annapragada, D.G. Gorenstein, T. Tanaka. Oncotarget 2(4), 298-304, 2011. Free PDF

(41) Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor binding domain III. S. Zhang, E. E. Bovshik, R. Maillard, G. D. Gromowski, D. E. Volk, C. H. Schein, C.Y.-H. Huang, D. G. Gorenstein, J. C. Lee, A. D. T. Barrett, D. W. C. Beasley Virology 403: 85-91, 2010. PMC2897250 (Free PDF)

(40) 1H and 31P NMR-Based Lipidomics of Ethanol-Induced Fatty Liver. H. Fernando, S. Kondraganti, K. K. Bhopale, D. E. Volk, M. Neerathilingam, B. S. Kaphalia, B. A. Luxon, P. J. Poor, G. A. S. Ansari. Alcoholism: Clinical and Experimental Research, 34,: 1937-1947, 2010. PMC3095964 (Free PDF)

(39) 1H NMR-Based Metabonomic Investigation of Tributyl Phosphate Exposure in Rats. M. Neerathilingam, D. E. Volk, S. Sarkar, T. M. Alam, K. M. Alam, S. G. Ansari, B. A. Luxon. Toxicology Letters 199, 10-16, 2010 .

(38) 1H NMR Metabonomic Study of Rat Response to Tri-Phenyl Phosphate and Tri-Butyl Phosphate Exposure. T.M. Alam, K. M. Alam, M. Neerathilingam, D. E. Volk, S. Sarkar, G. A. Shakeel Ansari, B. A. Luxon. Metabolomics 6, 386-394, 2010.

(37) Allyltributylstannane. S. Castellino, D. E. Volk, N. T. Patil, Y. Yamamoto (2009) in Encyclopedia of Reagents for Organic Synthesis, Second Edition, Edited by: Leo A. Paquette, David Crinch, Philip Fuchs and Gary A. Molander. Wiley. ISBN 978-0-470-01754-8.

(36) Crotyltributylstannane. S. Castellino and D. E. Volk (2009) in Encyclopedia of Reagents for Organic Synthesis, Second Edition, Edited by: Leo A. Paquette, David Crinch, Philip Fuchs and Gary A. Molander. Wiley. ISBN 978-0-470-01754-8.

(35) Tin (IV) Chloride-Zinc Chloride. S. Castellino and D. E. Volk (2009) in Encyclopedia of Reagents for Organic Synthesis, Second Edition, Edited by: Leo A. Paquette, David Crinch, Philip Fuchs and Gary A. Molander. Wiley. ISBN 978-0-470-01754-8.

(34) Tin (IV) Chloride. S. Castellino, D. E. Volk and C. J. Chany (2009) in Encyclopedia of Reagents for Organic Synthesis, Second Edition, Edited by: Leo A. Paquette, David Crinch, Philip Fuchs and Gary A. Molander. Wiley. ISBN 978-0-470-01754-8.

(33) Structure of Yellow Fever Virus Envelope Protein Domain IIID. E. Volk, F. J. May, S. H. Gandham, A. Anderson, J. von Lindern, D. Beasley, A. D.T. Barrett and D. G. Gorenstein. Virology 394, 12-18, 2009. PMC2787094 (Free PDF)

(32) Investigation of Chemometric Instrumental Transfer Methods for High-Resolution NMR. T. M. Alam, M. K. Alam, S. K. McIntyre, D. E. Volk, M. Neerathilingam and B. A. Luxon. Analytical Chemistry 81, 4433-4443, 2009.

(31) NMR Assignments of the Sylvatic Dengue 1 Virus Envelope Protein Domain III. D. E. Volk, K. M. Anderson, S. H. A. Gandham, F. J. May, L. Li, David W. C. Beasley, A. D. T. Barrett and D. G. Gorenstein. Biomol. NMR Assignments 2, 155-157, 2008. PMC2593834 (Free PDF)

(30) Base-pairing Properties of the Oxidized Cytosine Derivative, 5-Hydroxy Uracil. V. Thiviyanathan, A. Somasunderam, D. E. Volk, T.K. Hazra, S. Mitra and D. G. Gorenstein. Biochem. Biophys. Res. Commun. 366, 752-757, 2008. PMC2262052 (Free PDF)

(29) Ab initio base-pairing energies of an oxidized thymine product, 5-formyluracil with standard DNA bases at the BSSE-free DFT and MP2 theory levels. D. E. Volk, V. Thiviyanathan, A. Somasunderam and D. G. Gorenstein. Org. Biomol. Chem. 5(10), 1554-1558, 2007.

(28) NMR Assignments of the Yellow Fever Virus Envelope Protein Domain III. D. E. Volk, S. A. Gandham, F. J. May, A. Anderson, A. D. T. Barrett and D. G. Gorenstein. Biomolecular NMR Assignments 1(1):49-50, 2007.

(27) Solution Structure of the Envelope Protein Domain III of Dengue-4 Virus. D. E. Volk, Y.-C. Lee, X. Li, V. Thiviyanathan, G. D. Gromowski, L. Li, A. Lamb, D. W. Beasley, A. D. T. Barrett and D. G. Gorenstein. Virology 364(1), 147-154, 2007. (PMCID: PMC1950219)

(26) NMR Assignment of the Dengue 4 Virus Envelope Protein Domain III. D. E. Volk, Y.-C. Lee, X. Li, A. D. T. Barrett and D. G. Gorenstein. Journal of Biomolecular NMR 36(suppl. 5):62, 2006.

(25) Ab Initio Base-pairing Energies of Uracil and 5-Hydroxy-Uracil with Standard DNA Bases at the BSSE-free DFT and MP2 Theory LevelsD. E. Volk, V. Thiviyanathan, A. Somasunderam and D. G. Gorenstein. Organic and Biomolecular Chemistry 4(9), 1741-1745, 2006.

(24) Structure of the Envelope Protein Domain III of Omsk Hemorrhagic Fever Virus. D. E. Volk, L. Chavez, D. W. C. Beasley, A. D. T. Barrett, M. R. Holbrook and D. G. Gorenstein. Virology 351(1), 188-195, 2006.

(23) NMR structure of the viral peptide linked to the genome (VPg) of poliovirus. C. Schein, N. Oezguen, D. E. Volk, R. Garimella, A. Paul and W. Braun 27(7), 1676-1684, 2006. PMC1629084 (Free PDF)

(22) Novel, structure-based mechanism for uridylylation of the genome-linked peptide (VPg) of picornaviruses. C. Schein, D. E. Volk, N. Oezguen, A. Paul and W. Braun. PROTEINS:Structure, Function, and Bioinformatics 63:719-726, 2006.

(21) Selection of Thioaptamers for Diagnostics and Therapeutics. X. Yang, H. Wang, D.W.C. Beasley, D. E. Volk, X. Zhao, B. A. Luxon, L. O. Lomas, N. Herzog, J. F. Aronson, A.D.T. Barrett, J. F. Leary and D. G. Gorenstein.  Annal. N. Y. Acad. Sci. 1082, 116-119, 2006.

(20) 5-Hydroxy Uracil Can Form Stable Base Pairs With all Four Bases in a DNA Duplex. V. Thiviyanathan, A. Somasunderam, D.E. Volk, and D.G. Gorenstein. Chemical Communications.2005(3), 400-402, 2005.

(19) TATA-Box Binding Protein Induces Structure in the Recombinant Glucocorticoid Receptor AF1 Domain. R. Kumar, D.E. Volk, J. Li, J.C. Lee, D.G. Gorenstein and E.B. Thompson. Proc. Nat. Acad. Sci. U.S.A. 101, 16425-16430, 2004. PMC534534 (Free PDF)

(18) Solution structure and antibody binding studies of the envelope protein domain III from the New York strain of West Nile virus. D.E. Volk, D. W. C. Beasley, D. A. Kallick, M.R. Holbrook, A.D.T. Barrett and D. G. Gorenstein.  J. Biolog. Chem. 279,38755-38761, 2004.

(17) 1H, 13C, and 15N resonance assignments for domain III of the West Nile Virus envelope protein. D.E. Volk, D. A. Kallick, M.R. Holbrook, D.W.C. Beasley, A.D.T. Barrett and D.G. Gorenstein. J. Biomol. NMR 29, 445-446. 2004.

(16) NMR Structure of the Apo-S100P protein. Y.-C. Lee, D.E. Volk, V. Thiviyanathan, Q. Kleerekoper, A.X. Gribenko, S. Zhang D.G. Gorenstein, G. I. Makhatadze and B. A. Luxon. J. Biomol. NMR 29, 399-402, 2004.

(15) Solution Structure of a Cis-Opened (10R)-N6- Deoxyadenosine Adduct of (9S,10R)-9,10-Epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a DNA Duplex. D.E. Volk, V. Thiviyanathan, J.S. Rice, B.A. Luxon, J.H. Shah, H. Yagi, J.M. Sayer, D.M. Jerina, and D.G. Gorenstein. Biochemistry 42, 1410-1420, 2003.

(14) Initiation of Repair of A:G Mismatches is Modulated by Sequence Context. A.M. Sanchez, D.E. Volk, D.G. Gorenstein, and R.S. Lloyd. DNA Repair 2(8), 863-878, 2003.

(13) Solution Structure, Dynamics and Thermodynamics of the Native State Ensemble of the Sem-5 C-terminal SH3 Domain. J.C. Ferreon, D.E. Volk, B.A. Luxon, D.G. Gorenstein and V.J. Hilser. Biochemistry 42, 5582-5591, 2003.

(12) Solution structure and design of dithiophosphate backbone aptamers targeting transcription factor NF-kappa B. D.E. Volk, X. Yang, S.M. Fennewald, D.J. King, S. Bassett, S. Venkitachalam, N. Herzog, B.A. Luxon, and D.G. Gorenstein. Bioorganic Chemistry 30, 396-419, 2002.

(11) An ab initio study of phosphorothioate and phosphorodithioate interactions with sodium cation. D.E. Volk, T.D. Power, D.G. Gorenstein and B.A. Luxon. Tetrahedron Letters 43, 4443-4447, 2002.

(10) Potential Double-Flipping Mechanism by E. coli MutY. P.G. House, D.E. Volk, V. Thiviyanathan, R.C. Manual, B.A. Luxon, D.G. Gorenstein, and R.S. Lloyd. Progress in Nucleic Acid Research and Molecular Biology 68, 349-364, 2001.

(9) NMR Evidence for Syn-Anti Interconversion of a Trans Opened (10R)-dA Adduct of Benzo[a]pyrene (7S,8R)-Diol (9R,10S)-Epoxide in a DNA Duplex. D.E. Volk, J.S. Rice, B.A. Luxon, H.J.C. Yeh, C. Liang, G. Xie, J.M. Sayer, D.M. Jerina, and D.G. Gorenstein. Biochemistry 39, 14040-14053, 2000.

(8) Structural Similarities between MutT and the C-Terminal Domain of MutY. D.E. Volk, P.G. House,V. Thiviyanathan, B.A. Luxon, S. Zhang, R.S. Lloyd and D.G. Gorenstein. Biochemistry (Rapid Report) 39, 7331-7336, 2000.

(7) 1H, 13C, and 15N resonance assignments of the C-terminal domain of MutY: An Adenine glycosylase active on G:A mismatches. D.E. Volk, V. Thiviyanathan, P.G. House, R.S. Lloyd and D.G. Gorenstein. J. Biomol. NMR 14, 385-386, 1999.

(6) Tin (IV) Chloride. S. Castellino and D.E. Volk. "Encyclopedia of Reagents for Organic Synthesis." Leo Paquette, Editor-in-Chief, Wiley: 1995.

(5) Allyltributylstannane. S. Castellino and D.E. Volk. "Encyclopedia of Reagents for Organic Synthesis." Leo Paquette, Editor-in-Chief, Wiley: 1995.

(4) Crotylstannane. S. Castellino and D.E. Volk in "Encyclopedia of Reagents for Organic Synthesis." Leo Paquette, Editor-in-Chief, Wiley: 1995.

(3) SnCl4/ZnCl2. S. Castellino and D.E. Volk "Encyclopedia of Reagents for Organic Synthesis." Leo Paquette, Editor-in-Chief, Wiley: 1995.

(2) Chelation Controlled Reactions of Et2AlCl and Carbomethoxy Substituted Dioxolanes. S. Castellino and D.E. Volk. Tetrahedron Letters 34, 967, 1993.

(1) Substituent Effects on the Gas Phase Acidity of Silane. M.S. Gordon, D.E. Volk, and D.R. Gano. J. Am. Chem. Soc.: 111, 9273, 1989.