Skip Navigation and Go To Content

Mammalian Cell Combinatorial Library

Mammalian Cell Combinatorial Library Graph 1

Directed evolution is an effective way of protein engineering and typically performed in microbial systems. Even mammalian cells support protein folding, proper post-translational modifications, and cellular signaling all critical for studying mammalian biology and developing therapeutics, conducting directed evolution in mammalian cells is largely handicapped due to lack of a robust method to construct high quality libraries. We develop a platform technology that meets all desired criteria of an ideal library construction in mammalian cells - single variant per cell, accurate genomic integration, uniform transcription level, and large diversity. We expect our method has broad applications for functional biopharmaceutical development in mammalian cells.

1825 Pressler Sarofim Research Building
Houston, TX 77030-3998 United States