Dr. Cristini was recently featured in the global dissemination publication: International Innovation, “What is mathematics?”, issue 191. You can view the article here or view the entire publication here.
Dr. Cristini has over 15 years of experience in working with biologists, pathologists, physicians, and imaging scientists to study tumor growth and invasion and chemotherapy drug transport by using a combined mathematical modeling and experimental/clinical approach, aimed at helping develop individualized modeling-aided treatment strategies. Notably, he is leading a multi-institutional research effort on developing tissue-scale mechanistic biophysical models for predicting tumor response to treatment in individual patients using standard clinical diagnostic measurements, such as histopathology, CT, and MRI.
His current research projects include:
- Biophysical theories to predict the growth and invasion and drug response in local and metastatic cancers;
- Predictive tumor models using continuum, discrete, hybrid, and statistical approaches;
- Upscaling and downscaling framework (i.e., functionally linking biological behaviors at different scales);
- Drug pharmacokinetics and pharmacodynamics (PKPD) models.
1. HB Frieboes, ME Edgerton, JP Fruehauf, FRAJ Rose, LK Worrall, RA Gatenby, M Ferrari, V. Cristini. Prediction of drug response in breast cancer using integrative experimental/computational modeling. Cancer Res 2009 69: 4484-4492. PMC2720602
2. EL Bearer, JS Lowengrub, Y-L Chuang, HB Frieboes, F Jin, SM Wise, M Ferrari, D Agus, V Cristini. Multiparameter Computational Modeling of Tumor Invasion. Cancer Res 2009 69: 4493-4501. PMC2835777
3. V. Cristini, J. S. Lowengrub. Multiscale modeling of cancer: an integrated experimental and mathematical approach. Cambridge: Cambridge University Press (2010).
4. Edgerton, M., Y. Chuang, P. Macklin, W. Yang, E. L. Bearer, V. Cristini (2011). A Novel, Patient-Specific Mathematical Pathology Approach For Assessment Of Surgical Volume: Application To Ductal Carcinoma In Situ Of The Breast. Anal. Cell. Pathol. 34:247-63. PMC3613121
5. HB Frieboes, BR Smith, YL Chuang, K Ito, AM Roettgers, SS Gambhir, V Cristini. An integrated computational/ experimental model of lymphoma growth. PLoS computational biology. (2013) 9:e1003008. PMC3610621
6. Das, H., Wang, Z., Niazi, K., Aggarwal, R., Lu, J., Kanji, S., Das, M., Joseph, M., Gurcan M., Cristini, V. Impact of Diffusion Barriers to Small Cytotoxic Molecules on the Efficacy of Immunotherapy in Breast Cancer. PLoS One. (2013) 8:e61398. PMC3631240
7. Pascal J, Bearer EL, Wang Z, Koay EJ, Curley SA, Cristini V. Mechanistic patient-specific predictive correlation of tumor drug response with microenvironment and perfusion measurements. Proc Natl Acad Sci U S A (2013) 110: 14266-14271. PMC3761643
8. Pascal J, Ashley CE, Wang Z, Brocato TA, Butner J, Carnes EC, Koay EJ, Brinker CJ, Cristini V, Mechanistic modeling identifies drug-uptake history as predictor of tumor drug resistance and nanocarrier-mediated response. ACS Nano (2013) 7(12):11174-82. PMC3891887
9. E Koay, M Truty, V Cristini, et al., Transport properties of pancreatic cancer describe gemcitabine delivery and response. J Clin Invest (2014) 124: 1525-36. PMC3973100 (VC co-first author).
10. Koay EJ, Baio FE, Ondari A, Truty MJ, Cristini V, et al. Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer. Physical biology. 2014;11:065002. PMC4266401