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UTHealth pediatricians open Dysautonomia Center of Excellence

HOUSTON – (June 3, 2014) – Multi-disciplinary pediatric specialists at The University of Texas Health Science Center at Houston (UTHealth) Medical School have formed the UTHealth Dysautonomia Center of Excellence to bring research and treatment to a little-known, but potentially debilitating, disease.

Dysautonomia is caused by a dysfunction of the autonomic nervous system, which regulates all the unconscious functions of the body from the heart beat to breathing. It can affect the cardiovascular, gastrointestinal, metabolic and endocrine systems, causing organs throughout the body to work improperly.

“For example, the heart can stop beating, there can be convulsions and seizures, fainting, incontinence, vomiting, pallor and blotchy rashes. It’s a disease of multiple organs,” said Ian Butler, M.D., the Adriana Blood Professor Pediatrics and director of the Division of Child and Adolescent Neurology at the UTHealth Medical School. “We’ve recognized it in adults for some time. What is new is the recognition of the onset in children.”

Other symptoms can include nausea, headache, blood pressure fluctuations, fatigue, brain fog, increased heart rate, skin ailments, increased sweating and muscle aches.

Butler and Mohammed T. Numan, M.D., associate professor in the Division of Cardiology at the UTHealth Medical School, are co-directors of the new center, which includes 13 research studies and 540 UT Physicians clinic patients. Butler is also the Geissler Distinguished Chair in West Syndrome Research. Both are attending physicians at Children’s Memorial Hermann Hospital.

“Our multi-disciplinary center allows us to take a physiological approach and then tailor the medications and other treatments,” Numan said. “Some of these children have waited a long time to be diagnosed. They’ve been told ‘it's in their head.’ From testing to treatment, we’re turning it from subjective to objective.”

Because the damage from dysautonomia is often invisible – chronic fatigue is one of the most common symptoms – the disease can be missed. For diagnosis, the center uses a physiological tilt-table test, which involves placing the patient on a special table with a foot support. The table is tilted upward while two special monitors measure brain blood flow, blood circulation through the chest, sympathetic and parasympathetic tone changes, muscle blood flow and peripheral blood resistance.

The center’s multidisciplinary pediatric team includes Melissa R. Van Arsdall, M.D., assistant professor of gastrointestinal medicine; Ricardo Mosquera, M.D., assistant professor of pulmonology; Susan Pacheco, M.D., associate professor of allergy, immunology and rheumatology; Allison G. Dempsey, Ph.D., assistant professor of psychology; Anand Gourishankar, M.D., assistant professor of community and general pediatrics; Cindy K. Jon, assistant professor of pulmonology/sleep medicine; Holly Varner, M.D., assistant professor of neurology; and Rebecca Martinez, research nurse, UTHealth and Children’s Memorial Hermann Hospital.

Research related to dysautonomia includes studies on tilt-table testing, cerebrospinal fluid transmitters, neuropathy, atrial septal defects and migraine, mitochondrial disorders, gastrointestinal disorders, DNA analysis in families and the role of histamine and mast cells.

For more information, call 832-325-7118. To make an appointment, call 832-325-6516.

Deborah Mann Lake
Media Contact: 713-500-3030