Core Lab News
Mass spectrometry, laser microdissection services available
Hongyu Wang, M.D., Ph.D., director of Clinical and Translational Proteomics Service Center
The Clinical and Translational Proteomics Service Center provides state-of-the-art mass spectrometry instrumentation and laser microdissection services to The University of Texas Health Science Center at Houston (UTHealth) and the surrounding research community. The service center offers collaborative research requiring advanced methods and can customize services to suit individual projects.
Clinical and Translational Proteomics Service Center
Fayez S. Sarofim Research Building
1825 Pressler Street, SRB 301I.05
Houston, TX 77030
Monday-Friday 8:30 a.m.-5 p.m.
Overview of services
Basic services are designed to identify and quantitate proteins and their modifications in a broad range of research specimens, from simple purified protein samples to biomarker discovery, and verification in complex mixtures such as cell and tissue extracts, plasma and/or other biofluids.
Mass spectrometry, laser microdissection instruments
The service center contains the latest and most advanced instrumentation and trained personnel provide sample preparation services and analysis of research specimens. Mass spectrometry instruments are operated by our trained staff. Customers can submit samples to the core lab, where staff members process samples for digestion, cleaning and run mass spectrometry analysis.
- Thermo Orbitrap Fusion Tribid mass spectrometer,
- Thermo LTQ Orbitrap XL-ETD mass spectrometer,
- Agilent 6430 Triple Quadrupole LC/MS,
- Agilent 6538 Ultra High Definition Accurate-Mass Q-TOF LC/MS system
The service center’s Image Oriented Navigation Laser Microdissection Device (ION LMD Pro) can produce quality material for extensive and varied DNA, RNA and protein analyses. The ION LMD Pro enables a wide range of applications from single-cell isolation to large biopsy extractions, even with fluorescence-labeled cells or tissue. Customer training is available for the ION LMD Pro. Upon training completion, customers can operate the equipment.
Manuscripts and grant writing support
Assistance is available for collaborative manuscripts and grant writing for internal and external applications. Our efforts have led to several scientific publications including, “Improving vascular maturation using non-coding RNAs increases anti-tumor effect of chemotherapy” in Journal of Clinical Investigation Insight and funding awards like “Discovery of Novel Pathways Leading to Delayed Cerebral Ischemia after Subarachnoid Hemorrhage” from the National Institutes of Health and Center for Clinical and Translational Sciences.
Contact the Clinical and Translational Proteomics Service Center
For questions or scheduling requests, contact Li Li, lab manager, at Li.Li@uth.tmc.edu or 713-500-2456.