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Office of Research

Research Service Centers

UTHealth encourages the development of collaborative relationships among faculty around research and academic mission-related interests. To that end, UTHealth enables academic departments, schools, and the university itself to establish fee-for-service research service centers (“RSC”), and other research facilities and services for specific purposes in pursuit of these missions. To learn more about the policies governing the development and administration of RSCs, see Development and Administration of Research Service Centers.

To download a comprehensive pdf containing information about Research Resources at UTHealth, please see our UTHealth Research Resources Brochure

To learn more about UTHealth's Shared Research Resources, make a selection from the list below or scroll down to see descriptions and contact information.

Shared Research Resources

 

 

ResourceDescription of Services

 Atomic Force Microscopy Facility

Ana Maria Zaske, PhD

Ana.M.Zaske@uth.tmc.edu

713-486-5418

Services include:
  • AFM imaging combined with bright-field/fluorescence microscopy
  • Topographical imaging of samples in air or liquid environments
  • High-resolution imaging
  • Time-lapse experiments that show real-time changes in sample morphology or structure
  • Nano-probing of samples to measure the interaction of forces between molecules
  • Studies of local micromechanical properties of samples (elasticity, stiffness, roughness)
  • Data analysis for determination of homogeneity of samples, size distribution, position, mapping and 3D imaging.

Bioinformatics & High Performance Computing Service Center

W. Jim Zheng, PhD

Wenjin.J.Zheng@uth.tmc.edu


713- 500-3641

The UTHealth Bioinformatics Service Center provides expertise to process and analyze biological data. Center faculty focus on gene expression, genotyping, proteomics, metabonomics, and next-generation sequencing data and can also perform custom or other complex analyses. Additional services available include experiment design and assistance in developing grant applications and manuscripts.

Biomedical Informatics

Susan C. Guerrero

Susan.C.Guerrero@uth.tmc.edu


713-500-3926

A diverse group of Informaticians and IT professionals with backgrounds in Computer Science, Applied Mathematics, Project Management, Library Sciences, Biology. We collect, interpret, and manage data for the support of clinical and translational research. As co-investigators we develop new methods for reusing data for research.

Center for Advanced Microscopy

Olga Chumakova, Ph.D.

Olga.Chumakova@uth.tmc.edu

713-500-7495

The Center for Advanced Microscopy is a state of the art microscopy facility which directly supports the Department of Integrative Biology and Pharmacology. The facility is available for use by scientists within UTHealth and the Texas Medical Center. Available equipment includes:

Center for Laboratory Animal Medicine & Care (CLAMC)

CLAMC is responsible for the health and well being of laboratory animals used for the institution's biomedical research programs. CLAMC works in tandem with the institutional Animal Welfare Committee, and it meets all standards mandated by the Animal Welfare Act, Center for Disease Control, National Research Council Guide for the Care and Use of Laboratory Animals, Association for Assessment and Accreditation of Laboratory Animal Care - International, and the Public Health Service Policy on Humane Care and Use of Laboratory Animals.

Small Animal Cardiovascular Phenotyping Service Center

Siddharth Prakash, MD, PhD

Siddharth.k.Prakash@uth.tmc.edu

713-500-7003

The Small Animal Cardiovascular Phenotyping Service Center at McGovern Medical School provides access to equipment and expertise for imaging and analysis of small animal cardiovascular physiology, including:

  • State-of-the-art Vevo 3100 echocardiography platform with VevoVasc Ultra software
  • Doppler system for high-velocity vascular flow measurements
  • Coda tail-cuff volume blood pressure recorder
  • ADInstruments PowerLab and LabChart Pro high-fidelity pressure recording system for use with Millar pressure catheters
  • Leica A60 S Stereo Microscope with image capturing system

DNA Sequencing and Genotyping Core Lab

Dongchuan Guo, PhD

Dongchuan.Guo@uth.tmc.edu

713-500-6849

The DNA Sequencing and Genotyping Core Lab, CCTS, provides consultative expertise, mentoring, and technical support for studies, while employing genetic technologies, including DNA sequencing, genotyping techniques, data collection, and statistical analyses. The DNA Sequencing and Genotyping Core Laboratory Program is composed of four major components:

  • Consultative and mentor-based support services that provide individual investigators with guidance in the design, application, and interpretation of their genetic studies
  • Expertise in issues relating to proper informed consent for genetic studies and genetic counseling for patients enrolled in the studies.
  • Sanger DNA sequencing and microsatellite and SNP genotyping services that generate preliminary data supporting translational genetic research studies.
  • Infrastructure for banking DNA and other samples from patient populations and management system for sample tracking.

Flow Cytometry
Service Center

Amy Hazen, PhD

Amy.Hazen@uth.tmc.edu

713-500-3612

The Flow Cytometry Service Laboratory is located at IMM-Molecular Imaging Center and operates three instruments: a BD FACSAria II Special Order Research Product, a BD FACSCalibur and a Luminex LX200. All instruments are available to off-site users on a fee for service basis. Training is also readily available. The BD FACSAriaII SORP is a state-of-the-art 19 parameter instrument equipped with six fiber-optic-linked solid-state lasers, a 355nm UV laser, a 488nm Blue laser, a 561nm Yellow-Green laser, a 640nm Red laser, a 405nm Violet laser, and a highly specialized 785nm Near-InfraRed laser, capable of detecting up to 17 fluorescent signals and simultaneous aseptic sorting of up to four rare cell populations. The BD FACSCalibur provides user-friendly multicolor analysis capabilities and is capable of detecting up to four fluorescent signals. The Luminex system enables the multiplex of up to 100 analytes in a single microplate well.

Transgenic and Stem Cells Service Center

Aleksey Domozhirov

Aleksey.Y.Domozhirov@uth.tmc.edu

713-500-2452

The Transgenic and Stem Cells Core Facility was established in 1998 and since that time, it has generated over 650 new transgenic and knock-out mouse animal models for investigators from UTHealth, as well as for scientists from numerous other academic institutions.

The stem cell lines that have been derived in the laboratory are highly effective for the generation of knock-out/ knock-in mice and for cell differentiation studies. In addition to the production, cryopreservation and re-derivation of genetically-engineered mice and rats, the services of the facility also include gene targeting, derivation of new cell lines and intellectual/technical support in different aspects of microsurgery, cell culture and stem cells research.

McGovern Medical School
Histology Lab

Richard A. Breckenridge

Richard.Breckenridge@uth.tmc.edu

713-500-6792

The Histology Labs at UTHealth Dept. of Pathology & Laboratory Medicine provide a full range of histopathologic services, including

  • Trimming, decalcification, processing and embedding of tissue samples
  • Both paraffin and frozen sectioning capabilities
  • A wide variety of routine and specialized stains
  • State of the art immunohistochemistry and immunofluorescent staining
  • Image analysis equipment and services
  • High quality results and rapid turnaround time

Clinical & Translational Proteomics Service Center

Li Li

Li.Li@uth.tmc.edu

713-500-2456

The Clinical and Translational Proteomics Service Center provides state-of-the-art instrumentation and services to the entire UTHealth and surrounding research community. Our center offers both routine services for faculty who cannot afford nor desire the purchase of their own mass spectrometry instrumentation and collaborative research requiring advanced methods. The center works in a collaborative fashion between faculty, students and staff to customize services to suit individual projects.

The state –of –art instrumentation:

  • Thermo LTQ Orbitrap XL-ETD mass spectrometer
  • Agilent's 6538 Ultra High Definition Accurate-mass Q-TOF
  • Agilent's 6430 Triple Quadrupole LC/ MS
  • Applied Biosystems/MDS SCIEX QSTAR Elite Mass Spectrometer

A full range of the services:

  • Protein identification from 1D gel bands, 2-D spots and other matrices
  • Molecular weight determination, peptide and protein QC
  • Targeted Proteomics (SRM) for biomarker discovery as well as quantitation of selected proteins or peptides in a complex mixture
  • Biomarker discovery and verification
  • Pharmaceutical protein QA & QC
  • Characterization of immunoprecipitated or affinity-purified proteins and protein complexes
  • Global protein profiling with quantitative comparisons between samples (Label free, iTRAQ, SILAC etc)
  • Enrichment and characterization of post-translationally modified proteins and peptides

Magnetic Resonance Imaging (MRI) Facility

Nelly Arias

Nelly.Arias@uth.tmc.edu 

713-500-7583

The main emphasis of the MR research group at the McGovern Medical School at UTHealth is the development and application of advanced magnetic resonance imaging (MRI) techniques, including selective tissue imaging, magnetic resonance spectroscopic imaging, diffusion tensor imaging to neurological disorders, central nervous system trauma, and drug addiction both in humans and animal models.

Another major emphasis of our research is the development of novel image processing techniques that are robust and automatic for handling large number of images that are typically encountered in multi-center clinical trials.

The laboratory facilities include a 7 Tesla, state-of-the-art MRI scanner dedicated to animal studies with a fully equipped animal surgical suite, a research dedicated 3 Tesla whole body scanner, and an image processing laboratory with a high performance computing cluster and GPU processing.

Medical School Beckman-Coulter Gallios Flow Cytometer

Jacob Couturier, PhD

Jacob.couturier@uth.tmc.edu

713-500-7228

Services include:

Beckman-Coulter Gallios Flow Cytometer (3 lasers / 10 colors)

Kaluza Analysis Software

Pre-Clinical Computed Tomography (CT) Facility

Delia Danila, PhD

Delia.Danila@uth.tmc.edu

713- 486-6531 

The Preclinical CT is a core lab within the McGovern Medical School at UTHealth, featuring a rare CT system specialized for rapid high resolution imaging of objects up to size of large rabbits. The facility utilizes the The GE eXplore Ultra which provides high-quality images with contrast to-noise, resolution and dose performance optimized for pre-clinical imaging. As a non-profit service provider, costs are relatively low at $275/hr; with the system’s high throughput, the per-scan cost is often less than $25. Pricing for non-academic groups is $550/hr.

Quantitative Genomics and Microarray Facility

Tuan Tran

Tuan.M.Tran@uth.tmc.edu

713-500-7483

The Quantitative Genomics & Microarray Service Center provides investigators access to state-of-the-art detection technologies, automation and expertise for a variety of scientific methodologies. The facility can perform all techniques associated with a qPCR instrument, quantitative Meso Scale ELISAs and microarrays utilizing Illumina and Agilent arrays.

Nanochemistry Service Center

David Volk, PhD

David.Volk@uth.tmc.edu

713-500-3672

The Nanochemistry Service Center provides custom synthesis, labeling, and chemical coupling of DNA thioaptamers and nanoparticles. The Director and Lab Manager are both Ph.D. chemists with years of experience in DNA synthesis, especially the more difficult monothioated and dithioated DNA. In addition, they have conjugated numerous dyes, chelators, chemical linkers, and DNA spacers onto DNA. They have conjugated such DNA aptamers to liposomes, gold nanoparticles and mesoporous silicon particles for multi-stage vectors.

Cellular Therapy Core

Fabio Triolo, Ph.D.

Fabio.Triolo@uth.tmc.edu

 713- 486-2542 

The Cellular Therapy Core (CTC) consists of the Judith R. Hoffberger Cellular Therapeutics Laboratory and the Evelyn H. Griffin Stem Cell Therapeutics Research Laboratory. The Hoffberger laboratory is located on the 6th floor of the Medical School Building and is focused on translating, scaling-up, validating and supporting IND applications (CMC section) of promising new therapeutic technologies developed by scientists and physicians at a preclinical level into clinical-grade processes that can be used to manufacture cell-based and/or tissue engineered products for clinical applications. The Griffin Laboratory is located on the 6th floor of the Behavioral and Biomedical Sciences Building (BBSB) and is an FDA-registered facility accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) for Cellular Therapy Product Processing with more than minimal manipulation (see accreditation certificate). In the Griffin lab, tissues and organs are processed to produce cells for clinical applications in compliance with current Good Manufacturing Practice (cGMP).

Among services provided by the CTC are:

  • Early involvement of experts in regulatory issues and process development
  • Development and/or translation, optimization, scale-up and validation of manufacturing processes
  • Development and writing of Standard Operating Procedures (SOPs)
  • Development and validation of protocol-specific quality control (QC) assays
  • Support of IND applications (CMC section)
  • cGMP-compliant manufacturing of clinical-grade cell and/or tissue engineering products

Clinical Research Unit (CRU)

Kathy Franco, RN

Kathy.D.Franco@uth.tmc.edu

713-704-4147

The mission of the CCTS CRUs is to facilitate clinical research by providing investigators with specialized facilities, personnel, and advice. Investigators from CCTS institutions (UTHealth, M. D. Anderson Cancer Center, and Memorial Hermann Hospital System) can use any of the CCTS CRUs, depending on the location of their patients and the availability of services at the CRUs.

Biobank

Angela Baker Wimberly

UTHealth_CCTS_Biobank@uth.tmc.edu

713-500-2092

The CCTS Biobank consists of human samples and related clinical data owned by contributing investigators within the Texas Medical Center. More than 14,800 samples have been distributed to 53 researchers since 2002. The CCTS Biobank is decentralized; sample inventory and data reside with the contributing principal investigators.

The following sample types are available:

  • plasma
  • serum
  • DNA
  • buffy coat

The major disease categories include:

  • cardiovascular diseases
  • aneurysms
  • cancer
  • autoimmune system disorders