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Sunil Sheth, MD

Sunil Sheth, MD

Assistant Professor, Neurology
Co-Director, Vascular Neurology Fellowship Program

Dr. Sheth is originally from Houston, TX and attended Harvard University, graduating magna cum laude with an A.B. in Chemistry and Physics.  He received his M.D. from Harvard Medical School and Massachusetts Institute of Technology where he was enrolled in the Health Sciences and Technology Program. He graduated magna cum laude and was also awarded a Howard Hughes Medical Institute Research Fellowship. He completed his residency in Neurology at the University of California, San Francisco where he served as the chief resident, and fellowships in Vascular Neurology and Interventional Neuroradiology at the University of California, Los Angeles. Dr. Sheth is currently an Assistant Professor of Neurology at UT Health McGovern Medical School.

Dr. Sheth has co-authored many studies, which have been published in Cell, Nature Biotechnology, PlosONE, and the Journal of NeuroInterventional Surgery. For his research work he has been awarded grants from the American Heart Association (AHA), Society for NeuroInterventional Surgery Foundation, and National Institutes of Health. He has also received numerous honors and awards including the AHA International Stroke Conference Junior Investigator Travel Award, American Academy of Neurology (AAN) Resident Scholarship Award, American Society of Neuroradiology Trainee Award, and the Henry Asbury Christian Award for Excellence in Independent Research from Harvard University.

Education & Training

Undergraduate

Harvard College, Cambridge MA

Medical

Harvard Medical School, Boston, MA

Internship

Stanford University, Stanford, CA

Residency

Neurology, University of California San Francisco, San Francisco, CA

Fellowship

Vascular Neurology, University of California Los Angeles, Los Angeles, CA

Fellowship

Interventional Neuroradiology, University of California Los Angeles, Los Angeles, CA

Board Certifications

American Board of Psychiatry and Neurology, Certification in Neurology

American Board of Psychiatry and Neurology, Certification in Vascular Neurology

Areas of Interests

Clinical Interests

Ischemic Stroke
• Intracranial Hemorrhage
• Subarachnoid Hemorrhage
• Endovascular treatments for stroke
• Endovascular treatments for cerebral aneurysms
• Cerebral vascular malformations including arteriovenous malformations and arteriovenous fistulas
• Spinal vascular malformations
• Facial vascular malformations
• Tumor embolization

Clinical Interests

Ischemic Stroke
• Intracranial Hemorrhage
• Subarachnoid Hemorrhage
• Endovascular treatments for stroke
• Endovascular treatments for cerebral aneurysms
• Cerebral vascular malformations including arteriovenous malformations and arteriovenous fistulas
• Spinal vascular malformations
• Facial vascular malformations
• Tumor embolization

Research Interests

Endovascular stroke therapy
• Perfusion angiography
• Neuroimaging
• Biomarkers of cerebral injury
• Endovascular device development
• Traumatic brain injury

Research Information

His research focuses on the application of NeuroImaging in acute stroke, particularly related to endovascular stroke therapy (EST). He directs the UTHealth Stroke Institute Acute NeuroImaging Core and his laboratory serves as the Imaging Core Lab for a large multi-center EVT Registry (COMPLETE).  His laboratory is highly experienced in the application of machine based learning approaches. Dr. Sheth in collaboration with Luca Giancardo, PhD at our School of Biomedical Informatics is developing much-needed application tools for multi-modal CT based selection of stroke patients in the community setting to determine which patients would benefit from long distance transfer to specialized centers for EST.  He is funded by a 3-year career award from the American Academy of Neurology and the American Brain Foundation and is on the steering committee for the TESLA trial testing the efficacy of EST for patients with large infarcts.

Publications

  1. Pagliarini D, Calvo S, Chang B, Sheth SA, et al. “A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology.” Cell 134(1), 112-123 (2008).
  2. Calvo S, Jain M, Xie X, Sheth SA, Chang B, Goldberger O, Spinazzola A, Zeviani M, Carr S, Mootha VK. “Systematic identification of human mitochondrial disease genes through integrative genomics.” Nature Genetics 38(5), 576-582 (2006).
  3. Carter BS, Sheth SA, Chang E, Sethi M, Ogilvy CS. “Epidemiology on the size distribution of intracranial bifurcation aneurysms: smaller size of distal aneurysms and increasing size of unruptured aneurysms with age.” Neurosurgery 58(2), 217-223 (2006).
  4. Gohil V*, Sheth SA*, et al. “Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.” Nature Biotechnology. 28, 249–255 (2010).
  5. Antonietti L, Sheth SA, Halbach VV, Higashida RT, Dowd CF, Lawton MT, English JD, Hetts SW, “Long-term outcomes in the repair of spinal cord perimedullary arteriovenous fistulas.” American Journal of Neuroradiology. 31: 1824 (2010).
  6. Sheth S, Sheth SA, Ogilvy CS. “Craniectomy Rationale: Outcomes Data and Surgical Techniques” in Hemorrhagic and Ischemic Stroke: Surgical, Interventional, Imaging, and Medical Approaches. Bendok et al. [ed.], Thieme Publishers (2011).
  7. Gohil V, Offner N, Walker J, Sheth SA, Fossale E, Gusella J, MacDonald M, Neri C, Mootha VK, “Meclizine is neuroprotective in models of Huntington’s Disease.” Human Molecular Genetics. 20 (2): 294-300 (2011).
  8. Sheth SA, Yee AH. “An Unexpected Complication of Intravenous Thrombolysis for Acute Ischemic Stroke.” Neurology. 81(7): e42-43 (2013).
  9. Sheth SA, Potts MB, Sneed PK, Young WL, Cooke DL, Gupta N, Hetts SW. “Angiographic features help predict outcome after stereotactic radiosurgery for the treatment of pediatric arteriovenous malformations.” Child’s Nervous System. (2013). doi:10.1007/s00381-013-2231-4
  10. Sheth SA, Hausrath D, Numis AL, Lawton MT, Josephson SA. “Intraoperative re-rupture in surgical treatment of subarachnoid hemorrhage does not lead to increased vasospasm.” Journal of Neurosurgery. (2013). doi: 10.3171/2013.10.JNS13934
  11. Sheth SA, Noorian AR, Liebeskind DS. “Cerebral Hemodynamics and Homeostatic Mechanisms” in Brain Mapping: An Encyclopedic Reference. Toga et al. [ed.], Elsevier Publishers. March, 2015.
  12. Sheth SA, Liebeskind DS. “Imaging Evaluation of Collaterals in the Brain: Physiology and Clinical Translation.” Current Radiology Reports. 2(29): 1-9 (2014). doi:10.1007/s40134-013-0029-5
  13. Jain M, Ngoy S, Sheth SA, Rhee, EP, Liao, R, Clish, CB, Mootha, VK, and Nilsson, R. “A systematic survey of major lipid species across mammalian tissues.” American Journal of Physiology – Endocrinology and Metabolism 306, E854-E868 (2014). doi:10.1152/ajpendo.00371.2013
  14. Sheth SA, Noorian AR, Nogueira R, Liebeskind DL. “Watching, but not Waiting: Vascular Neurology Perspective on the Disparate Regulatory Pathways for Stroke.” Journal of NeuroInterventional Surgery (2014). doi: 10.1136/neurintsurg- 2014-011146
  15. Sheth SA, Yoo B, Saver JL, Starkman S, Ali LK, Kim D, Gonzalez NR, Jahan R, Tateshima S, Duckwiler G, Vinuela F, Liebeskind DS. “M2 Occlusions as Targets for Endovascular Therapy: Comprehensive Analysis of Diffusion/Perfusion MRI, Angiography, and Clinical Outcomes.” Journal of NeuroInterventional Surgery. (2014). doi:10.1136/neurintsurg-2014-011232
  16. Potts MB, Sheth SA, Louie J, Smyth MD, Sneed PK, McDermott MW, Lawton MT, Young WL, Hetts SW, Fullerton FJ, Gupta N. “Stereotactic radiosurgery at a low marginal dose for the treatment of pediatric arteriovenous malformations: obliteration, complications, and functional outcomes.” Journal of Neurosurgery: Pediatrics. (2014). doi: 10.3171/2014.3.PEDS13381
  17. Sheth SA, Sanossian N, Hao Q, Starkman S, Ali LK, Kim D, Gonzalez NR, Tateshima S, Jahan R, Duckwiler G, Saver, JL, Vinuela F, Liebeskind DS. “Collateral flow as causative of good outcomes in endovascular stroke therapy.” Journal of NeuroInterventional Surgery(2014). doi: 10.1136/neurintsurg-2014-011438.
  18. Sheth SA, Liebeskind DS. “Collaterals in Endovascular Therapy for Stroke.” Current Opinion in Neurology. 28(1): 10-15 (2014).
  19. Chen Y, Brennan-Minella A, Sheth SA, El Benna J, Swanson R. “Tat-NR2B9c prevents excitotoxic neuronal superoxide production.” Journal of Cerebral Blood Flow and Metabolism (2015). 0:1-4. doi:10.1038/jcbfm.2015.16.
  20. Sheth SA, Jahan R, Levy EI, Jovin TG, Baxter B, Nogueira RG, Clark W, Budzik R, Zaidat O, Saver JL. “Rapid learning curve for Solitaire FR Stent Retriever therapy: evidence from roll-in and randomized patients in the SWIFT trial.” Journal of NeuroInterventional Surgery (2015). 0:1-6. doi:10.1136/neurintsurg-2014-011627
  21. Sheth SA, Saver JL, Starkman S. Letter to the editor regarding Berkhemer et al., January 1st 2015 issue. New England Journal of Medicine. 372(12): 1176-1179 (2015).
  22. Sheth SA, Saver JL, Starkman S, Grunberg ID, Guzy J, Ali LK, Kim D, Gonzalez NR, Jahan R, Tateshima S, Duckwiler G, Liebeskind DS. “Enrollment Bias: Frequency and Impact on Patient Selection in Endovascular Stroke Trials.” Journal of NeuroInterventional Surgery (2015). 0:1-7. doi:10.1136/neurintsurg-2014-011628
  23. Sheth SA, Patel NS, Ismail A, Freeman D, Duckwiler G, Tateshima S. “Treatment of Wide-Necked Basilar Tip Aneurysm Not Amenable to Y-Stenting Using the PulseRider Device.” British Medical Journal: Case Reports (2015). Doi: 10.1136/bcr-2015- 011836
  24. Sheth SA, Jahan R, Gralla J, Pereira VM, Nogueira RG, Levi EI, Zaidat OO, Saver JL. “Time to Endovascular Reperfusion and Degree of Disability in Acute Stroke.” Annals of Neurology (2015). doi: 10.1002/ana.24474
  25. Sheth SA, Iavarone AT, Liebeskind DS, Won SJ, Swanson RA. “Targeted Lipid Profiling Discovers Biomarkers of Acute Brain Injury.” PLoS ONE (2015). doi:10.1371/journal.pone.0129735
  26. Kamal H, Lopez V, Sheth SA. “Machine Learning in Acute Ischemic Stroke Neuroimaging.” Frontiers in Neurology (2018). doi: 10.3389/fneur.2018.00945
  27. Dula AN, Luby M, King BT, Sheth SA et al. “Neuroimaging evaluation of ischemia in men and women: an observational study.” Annals of Clinical and Translational Neurology (2019). Doi: 10.1002/acn3.733
  28. Saber H, Navi BB, Grotta JC, Kamel H, Bambhroliya A, Vahidy FS, Chen PR, Blackburn S, Savitz SI. McCullough L, Sheth SA. “Real-world Treatment Trends in Endovascular Stroke Therapy.” Stroke (2019). doi:10.1161/STROKEAHA.118.023967
  29. Lee S, Yoo AJ, Marquering HA, Berkhemer OA, Majoie CB, Dippel DWJ, Sheth SA for the MR CLEAN Investigators. “Accuracy of ‘At Risk’ Tissue Predictions Using CT Perfusion in Acute Large Vessel Occlusions.” Journal of NeuroImaging (2019). https://doi.org/10.1111/jon.12595
  30. Sheth SA, Lopez-Rivera L, Lee S, Savitz SI, Liebeskind D, Grotta JC. “14th International Symposium on Thrombolysis, Thrombectomy and Acute Stroke Therapy: Proceedings and summary of discussions.” International Journal of Stroke (2019). doi.org/10.1177/1747493019838760
  31. Barman A, Inam ME, Lee S, Savitz SI, Sheth SA*, Giancardo L*. “Determining Ischemic Stroke from CT-Angiography Imaging Using Symmetry-Sensitive Convolutional Networks.” IEEE International Symposium on Biomedical Imaging (2019).
  32. Saber H, Rajah G, Sheth SA. “Utilization and safety of extracranial-intracranial bypass surgery in symptomatic steno-occlusive disorders.” Brain Circulation (2019). Doi: 10.4103/bc.bc_33_18
  33. Hadley C, Sheth SA, Fargen KM, Srinivasan V, Cherian J, Chen S, Johnson J, Kan P. “Mechanical thrombectomy for acute stroke in patients with target and unrelated vessel AVMs and AVFs.” World Neurosurgery (2019). Doi: https://doi.org/10.1016/j.wneu.2019.04.019.
  34. Capoglu S, Savarraj J, Sheth SA, Choi HA, Giancardo L. “Representation learning of 3D brain angiograms, an application for cerebral vasospasm prediction.” International Conference of the IEEE Engineering in medicine and Biology Society (EBMC) (2019)
  35. Czap AL, Grotta JC, Parker SA, Yamal JM, Bowry R, Sheth SA, et al. “Emergency Department Door-to-Puncture Time Since 2014: Observations from the BEST-MSU Study.” Stroke (2019). https://doi.org/10.1161/STROKEAHA.119.025106