PhD Public Seminar: Benjamin Insley
When & Where
April 1, 2024
1:00 PM - 2:00 PM
FCT3.5001 ( View in Google Map)
Contact
- Academic Affairs
- [email protected]
Event Description
Proof-of-Concept for Converging Beam Small Animal Irradiator
Advisors: Mohammad Salehpour, PhD, and David Jaffray, PhD
The Monte Carlo particle simulator TOPAS, the multiphysics solver COMSOL®, and several analytical radiation transport methods were employed to perform an in-depth proof-of-concept for a high dose rate, high precision converging beam small animal irradiation platform. In the first aim of this work, a novel carbon nanotube-based compact X-ray tube optimized for high output and high directionality was designed and characterized. In the second aim, an optimization algorithm was developed to customize a collimator geometry for this unique X-ray source to simultaneously maximize the irradiator’s intensity and precision. Then, a full converging beam irradiator apparatus was fit with a multitude of these X-ray tubes in a spherical array and designed to deliver converged dose spots to any location within a small animal model. This aim also included dose leakage calculations for estimation of appropriate external shielding. The result of this research will be the blueprints for a full preclinical radiation platform that pushes the boundaries of dose localization in small animal trials.
Advisory Committee:
Mohammad Salehpour, PhD, Chair
David Jaffray, PhD, Co-Chair
Peter Balter, PhD
Dirk Alan Bartkoski, PhD
Khandan Keyomarsi, PhD
Surendra Prajapati, PhD
Ramesh Tailor, PhD
Attend via Zoom
Meeting ID: 851 7844 9424
Password: 495260
Proof-of-Concept for Converging Beam Small Animal Irradiator
Advisors: Mohammad Salehpour, PhD, and David Jaffray, PhD
The Monte Carlo particle simulator TOPAS, the multiphysics solver COMSOL®, and several analytical radiation transport methods were employed to perform an in-depth proof-of-concept for a high dose rate, high precision converging beam small animal irradiation platform. In the first aim of this work, a novel carbon nanotube-based compact X-ray tube optimized for high output and high directionality was designed and characterized. In the second aim, an optimization algorithm was developed to customize a collimator geometry for this unique X-ray source to simultaneously maximize the irradiator’s intensity and precision. Then, a full converging beam irradiator apparatus was fit with a multitude of these X-ray tubes in a spherical array and designed to deliver converged dose spots to any location within a small animal model. This aim also included dose leakage calculations for estimation of appropriate external shielding. The result of this research will be the blueprints for a full preclinical radiation platform that pushes the boundaries of dose localization in small animal trials.
Advisory Committee:
Mohammad Salehpour, PhD, Chair
David Jaffray, PhD, Co-Chair
Peter Balter, PhD
Dirk Alan Bartkoski, PhD
Khandan Keyomarsi, PhD
Surendra Prajapati, PhD
Ramesh Tailor, PhD
Attend via Zoom
Meeting ID: 851 7844 9424
Password: 495260