Office of Technology Management
University Center Tower (UCT)
7000 Fannin Street, Suite 720  
Houston, Texas 77030
Phone: (+1) 713-500-3369    
Fax: (+1) 713-500-0331
Email: otm@uth.tmc.edu

Latest Technologies

Improved Antibody-Drug Conjugate Linker Compositions and Methods of Use

Faculty members at the University of Texas Health Science Center at Houston have developed a novel chemical linker for constructing antibody-drug conjugates (ADCs). While traditional ADC linkers can only load a single payload molecule, the developed linker has the ability to load two identical or different drug payloads. Doubling the number of payloads increases the drug-to antibody ratio which can lead to enhanced potency in cell viability assays (as shown in animal model experiments). The novel linker system provides the opportunity to revisit payloads that are mechanistically attractive; pa...

Monoclonal Antibodies targeting EpCAM

AbstractEmbodiments of the invention provide high affinity recombinant EpCAM-binding antibodies. Methods of using a such antibodies as imaging agents, diagnostics and therapeutics are also provided. Dual-nuclear and fluorescently labeled or singly fluorescently labeled contrast agents promise the advantage of molecularly-guided surgical resection via surgical field near-infrared fluorescence (NIRF) imaging following (in the case of dual labeled agents) nuclear imaging for general localization. Currently, nodal staging of most cancers is performed following lymph node (LN) biopsy and dissection...

ebpABC gene deletion mutant TX5608 and E. faecalis strain OG1RF

Endocarditis and biofilm-associated pili (EbpABC) gene deletion of Enterococcus faecalis and WT parent bacteria OG1RF. See published research paper on these bacterial strains:  Research paper published:J Clin Invest. 2006 Oct;116(10):2799-807. Endocarditis and biofilm-associated pili of Enterococcus faecalis.Nallapareddy SR, Singh KV, Sillanpää J, Garsin DA, Höök M, Erlandsen SL, Murray BE.doi:10.1172/JCI29021

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