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Clot Burst Pressure (CBP) Measurement Device

Researchers from UTHealth designed a device for developing a clot burst pressure (CBP) which can be used for direct measurement of the pressure required to dislodge a clot. More particularly, this measurement can distinguish between thrombi of hypo- and hypercoagulable states by observing differences in the CBP of conditioned groups compared to control CBP. This has the potential to be applied for a better understanding of trauma pathophysiology, thus can help direct acute care to reduce mortality rates and associated morbidities due to inappropriate resusitation. Background Trauma is the le...

Identifying and characterizing genes whose perturbation leads to intracranial aneurysms (IA) and/or vascular endothelial cell dysfunction

The proposed invention involves identification and characterization of molecular targets for treating intracranial aneurysms. A focus is endothelial podosomes regulated by the transmembrane receptor protein THSD1. THSD1 also regulates autophagy processes that contribute to aneurysm formation as well as positively regulates TGFβ signaling, which may ameliorate IA disease. Technology Overview The technology is a novel therapeutic approach to treat intracranial aneurysms via elucidation and characterization of several genes involved in endothelial podosome formation, which has been shown to...

Directional and Scalable (DISC) Electrode Array

­Overview. A directional and scalable (DISC) electrode array has been developed and tested to provide improved performance while overcoming limitations seen in conventional neural sensors. The array design proposed here is an improvement on the state-of-the-art electroencephalogram (sEEG) by enabling the recording of spatially distinct local field potentials (LFP). This is achieved by radially positioning of electrodes around the array using advanced manufacturing techniques. The device demonstrates superior performance in terms of signal-to-noise (SNR), directional sensitivity, and deco...

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