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Office of Technology Management

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Office of Technology Management
University Center Tower (UCT)
7000 Fannin Street, Suite 1400
Houston, Texas 77030
Phone: (+1) 713-500-3369    
Fax: (+1) 713-500-0331
Email: otm@uth.tmc.edu


Latest Technologies

LGR4 Specific Monoclonal Antibodies and Their Use

­Researchers at UTHealth have isolated and characterized monoclonal antibodies as well as antibody fragments that specifically binding to LGR4, a 7TM receptor that is highly expressed in major types of solid tumors, including but not limited to colorectal cancer, non-small cell lung cancer, and ovarian cancer. These LGR4 specific monoclonal antibodies have the potential applications for cancer therapeutics, diagnosis and detection. Background Leucine-rich repeat-containing, G-protein coupled receptor 4 (LGR4) consists of a large extracellular domain with 17 leucine-rich repeats and a se...

Mutants and Drug Conjugates of R-Spondin Polypeptides for Cancer Therapy

­R-spondins (RSPOs) are secreted proteins with critical roles in cancer development through binding to LGRs and RNF43/ZNRF3 and potentiating Wnt signaling. Various RSPO mutants were discovered that bind to LGRs but no longer function in Wnt signaling.  Fc fusion protein of the RSPO mutants, so called RSPO peptibodies, were conjugated with cytotoxic drugs and the resulting conjugates were able to inhibit the growth of cancer cells expressing LGR4, LGR5 and/or LGR6 in vitro and in vivo without major adverse effect. Background RSPOs and LGR4-6 (leucine-rich repeat containing, G protein...

Deep Learning Based Method for Implanted Medical Devices Automatic Identification Using PACS

­Magnetic Resonance Imaging (MRI) is the most commonly used imaging modality for diagnosis and surveillance of various neurosurgical conditions, while patients usually need to undergo a rigorous screening process prior to MRI examination to ensure the implants they have are MR safe and assure patient safety. Researchers at UTHealth have developed a new pipeline to identify implantable device MRI compatibility using mobile phone quality images, which outperforms the other currently available methods, and has the potential to become a safety tool for radiologists to efficiently coordinate th...

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