Office of Technology Management
University Center Tower (UCT)
7000 Fannin Street, Suite 720
Houston, Texas 77030
Phone: (+1) 713-500-3369
Fax: (+1) 713-500-0331
Novel Channelrhodopsins for Optogenetics Gene Therapy When expressed in targeted neurons, light-sensitive channelrhodopsin proteins (ChRs) have the ability to selectively manipulate neuronal activity in a light-dependent manner. Gene therapy using anion ChRs (ACRs) has the potential for treating excessive neuron firing in conditions such as Parkinson’s disease, neuropathic pain and epilepsy, while cation ChRs (CCRs) hold promise for vision restoration. Dr. John Spudich and his team at UTHealth have developed suites of ACRs and CCRs, which are orders of magnitude more e...
Novel Compounds and Methods of Use for the Treatment and Prevention of Cancer via Inhibition of the K-Ras Pathway Background: The Ras protein family members belong to a class of proteins called small GTPases and when activated by incoming signals, it subsequently switches on other genes involved in cell growth, differentiation, and survival. As a result, mutations in the ras genes can lead to production of permanently activated Ras proteins and ultimately lead to cancer. Localization of K-ras to the plasma membrane is required for the activation of downstream effector pathways. Fe...
Summary Cognitive processes are brain operations that allow us to perform complex functions that are the very essence of being human—examples include but are not limited to memory, language, control over emotions, resolving conflicting information, reading, making decisions, puzzle solving etc. These functions are subject to various disorders produced by brain injury, aging, and to mental health disorders that primarily affect learning, memory, perception, and problem solving, and include amnesia, dementia, and delirium. Additionally psychiatric conditions like anxiety disorders, mood d...