The Wang laboratory uses functional genomics to study gene regulation. We develop and apply novel genomics tools to elucidate how genetic variants impact gene regulation and ultimately human health. The current focus of the lab is on translational regulation in the context of stress response. More specifically, we are taking a cis-QTL mapping approach to identify genetic variants associated with changes in translation efficiency in response to nutrient deprivation. In addition, in order to provide mechanistic explanations for the genetic associations identified, we are further developing novel methods for measuring/ inferring RNA binding protein occupancy and for identifying regulatory elements that control translation (e.g. uORFs). With the new data and novel methods, we aim to gain both fundamental understanding of gene regulation and useful information that is directly applicable for improving human health.