Our History

The Center was established by funds from the Texas Emerging Technology Fund, UTHealth and the Memorial Hermann Hospital Fund. The principle mission of our center is to lead in the research and development of next-generation medical technologies related to hemostasis, resuscitation, and computerized decision support for trauma patients. The need for translating trauma research from the bench to the bed side is as great a priority and CeTIR is in a unique position to link basic science research to clinical practice.

 

Our Mission

The mission of The Center for Translational Injury Research (CeTIR) is to lead in the research and development of next-generation medical technologies related to hemostasis, resuscitation, and computerized decision support for trauma patients

Employment Opportunities

NIGMS T32 Trauma Research Fellowship

Institutional Information:
Center for Translational Injury Research (CeTIR) and the Department of Surgery, McGovern Medical School, University of Texas Health Science Center at Houston

Address: 6410 Fannin St. Suite 1100, Houston, TX 77030
Email: erin.e.fox@uth.tmc.edu

Fellowship/Post-Doc Information:
Fellowship: NIGMS T32 Trauma Research Fellowship
Length: 2 Years
Total number of positions: 4 (1-3 available/year)
Program Director: Charles S. Cox, Jr., MD

Description:
The University of Texas Health Science Center at Houston (UTHealth) is currently seeking postdoctoral candidates for a National Institute of General Medical Sciences (NIGMS)-funded T32 research fellowship in the following research areas: traumatic brain injury, resuscitation (including hemorrhagic shock), and organ injury and/or dysfunction. These are two year fellowships devoted to clinical or translational research. UTHealth and its primary clinical site, Memorial Hermann Hospital, are located in the heart of the Texas Medical Center in Houston, the largest incorporated medical center in the world. UTHealth’s Trauma Research Training Program was created in 1988, and over the last 25 years, multidisciplinary faculty have successfully mentored residents and postdocs to become competitive, productive, and independent clinical researchers.

Program goals:
The goal of this comprehensive program is to provide mentorship as well as didactic and practical training in clinical and translational research, resulting in significant contributions to the care of traumatically-injured patients and future academic independence. Upon the completion of the fellowship, fellows will be able to 1) formulate focused research questions and develop appropriate protocols to answer those questions; 2) analyze the resulting data and draw appropriate conclusions from these data; 3) collaborate with other scientists in a multidisciplinary setting; and 4) organize both oral and written presentations of research results, defend conclusions, and translate them to the care of the traumatically-injured patient. Fellows will participate in didactic coursework, including courses in clinical trial design, scientific writing, epidemiology, biostatistics, ethics and career development and have the opportunity to complete a Master of Science in Clinical Research. T32 fellows will be directly advised by a primary faculty mentor at UTHealth.

Other requirements:
UTHealth provides equal employment opportunities, is committed to recruiting a talented and diverse workforce, and encourages applications from under-represented ethnic minorities and veterans. Applicants must have an MD or PhD and be a U.S. citizen or permanent resident.

HOW TO APPLY: Interested applicants should send a current CV, a one page statement of research interests, a half page statement of career goals and three letters of reference to erin.e.fox@uth.tmc.edu



Center Capabilities & Research Methodologies


Translating Science from the Bench to the Bedside
Jeanette Podbielski, RN; John B. Holcomb, MD; R. Michelle Sauer, PhD

OBJECTIVES/GOALS:

  • Assist with the translation of ideas from the basic science level to clinical studies
  • Assist with the translation between civilian and military populations
  • Evaluate and improve clinical practices
  • Test/validate new medical interventions
  • Implement new technologies to provide optimal trauma care and outcomes

METHODS:

Our approach to preparing research proposals is as follows:

  • Identify a clinical problem
  • Create data-driven questions
  • Based on the questions, determine the best approach to providing the answer (utilizing basic science and clinical or both)
  • Basic science research approach - helpful in evaluating the question through model systems that mimic the clinical problem
    • Model systems are done on a cellular level as well as animal level
    • Model systems look at PBBI, TBI, shock and hemorrhagic shock
    • Mesenchymal Stem Cell research for TBI and hemostasis
  • Clinical research approach - helpful in evaluating the question if it involves a large patient population
    • Examples include prospective, observational studies from trauma patients upon arrival to the ED
    • Questions to evaluate include: pre-hospital triage, blood transfusion practices, coagulopathy guidelines and utilization of clinical based algorithms.
  • Basic Science and Clinical Research approaches can interact and assist each other to provide answers to the proposed question.
  • Following completion of the studies, analysis is completed on data collected.
  • The analysis is reviewed and decisions are made to
    1. Propose changes to clinical care based on results
    2. Pose additional questions leading to additional studies.
    3. Provide results from the civilian studies to the military for potential clinical use.

AREAS OF INTEREST:

  • Pre-hospital triage
  • Earlier life saving interventions in the ED
  • Administration of blood products
  • Coagulopathy guidelines
  • Utilization of clinical based algorithms
  • Resuscitation computerized decision support
  • Long-term outcomes
  • Quality of life

RESULTS:

Currently, the clinical research team is participating in 20+ studies ranging from pre-hospital care to in-hospital resuscitation trials; interventional versus observational; and retrospective versus prospective.

Sponsorship is diversified among the state, the four military branches, industry, investigator initiated and NIH.

CONCLUSION:

Through collaborative efforts, our clinical team validates new devices and procedures to provide earlier treatment to the soldiers injured on the battlefield as well as test procedures and devices proven to be effective on the battlefield in the emergency setting of the civilian population. At the same time significant effort is put forth to observe and evaluate treatment protocols and patient populations to identify important patterns or trends.

 

Center Equipment

The 5th floor CeTIR laboratory has extensive equipment throughout the various rooms. Biological equipment include a Tecan Safire 2 microplate reader, Beckman Coulter Z1 particle counter, Wallace Victor2 multi-label counter, Beckman Coulter ViCell XR system, a Shandon cryotome, a Biorad C1000 thermo cycler, an Amaza 96-well nucleofector, a Forma incubated shaker, 4 CO2 incubators, a Heracell Trigas incubator, 4 six-ft tissue culture enclosures, a Rontanta 460R refrigerated benchtop centrifuge, a Sorvall Legend RT centrifuge, an Accuspin 17R micro-centrifuge, a Wescor 4420 colloid osmometer and Wescor 5520 vapor pressure osmometer and a blood gas analyzer (Nova Biomedical Stat Profile CCX).

Microscopy equipment include an Olympus IX71 fluorescence microscope with 10GB-optical camera mount, and 3 Olympus CKX41 tissue culture microscopes. Analytical equipment include a Shimadzu Pharmaspec 1700 UV/Vis spectrometer, a Malvern Zetasizer Nano-ZS system, a Perkim Elmer Spectrum A FTIR spectrometer, Waters A6 HPLC system, Barnstead D8981 Nanopure ultrapure water system, and a Labconco FreeZone 4.5 liter lyophilizer.

The core hemostasis lab includes a Calibrated Automated Thrombogram (CAT; Thrombinoscope, Maastricht, The Netherlands), ACL TOP automated coagulation analyzer (Beckman Coulter, Fullerton, CA), STAR4 coagulation analyzer (Stago), PAP-8 Platelet aggregometer (Bio-Data), two whole blood lummi-aggregometers (Chrono-Log), Multiplate whole blood aggregometer (Diapharma), Thromboelastograph (TEG; Haemoscope), Allegra X-12R refrigerated centrifuge (Beckman Coulter), Zymark gas evaporator, and an EPICS XL Flow cytometer and workstation (Beckman Coulter), TQ Prep Workstation (Beckman Coulter), E-Max microplate reader with computer, microplate washer, Luminometer, UV spectrophotometer, Waters HPLC system with Millennium software, PDA and INUS detectors, Milli-Q water system. There is also a dedicated space housing two Gallios Flow cytometers with 3 lasers and 10 colors (Beckman Coulter).

For in vivo imaging studies, the trainees have access to an explore Locus Ultra pre-clinical CT scanner with a fully automated animal bed that can accommodate animals up the size of rabbits. The high-resolution CT scanner is capable of quantitative anatomical and physiological measurements as well as 1 second volume data acquisition for full perfusion imaging.