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Director: Jon Tyson, MD, MPH – Jon.E.Tyson@uth.tmc.edu - 713-516-5429
Co-Directors: Charles C. Miller, III, Ph.D. - Charles.C.Miller@uth.tmc.edu; Matthew Rysavy, MD, Ph.D. - Matthew.A.Rysavy@uth.tmc.edu – 713-500-5651
Contact: Micquelyn “Micky” Titus – Micquelyn.Titus@uth.tmc.edu - 713-500-5651
New knowledge is generated in learning how to best apply research in treating patients and distinguish effective from ineffective or harmful therapies in “real world” clinical settings. Learning Healthcare (LHC) thus constitutes a paradigm shift from traditional views of patient care, quality improvement (QI), and research as separate and distinct activities. To date, the emphasis in LHC has been on observational studies. Such studies are crucial for generating new hypotheses, identifying rare treatment hazards, and assessing therapies that are not feasible or ethical to study in clinical trials. Unfortunately, even the most carefully designed and analyzed observational studies may involve unknown confounders or other sources of bias that result in widespread use of ineffective or even harmful therapies and contribute to repeated cycles of these treatments eventually being retired after more rigorous study. LHC in the CCTS addresses the use of rigorous and innovative interventional studies, particularly comparative effectiveness research (CER) and randomized QI studies, to avoid the confounding and unavoidable sources of bias in many observational studies, to distinguish effective from truly ineffective or harmful therapies in clinical practice, and augment “real world” care. A strength of our LHC program is its broad integration into other Components of our Clinical and Translational Science Award, including our KL2 and Institutional Scholars and Integrating Special Populations Components.
Consultation Services and Training
The CCTS provides consultation to researchers hoping to integrate LHC into their projects. Training and consultation in LHC is also provided through other CCTS programs, including the KL2 and Institutional Scholars and LHC Scholars programs and courses in the Master’s Program and Clinical Research Curriculum.
Examples of LHC Research
The following are just a few examples of research within the LHC component.