Publications of the CACD
From the past 5 years with impact factors >10
- Roy ER, Wang B, Wan YW, Chiu G, Cole A, Yin Z, Propson NE, Xu Y, Jankowsky JJ, Liu Z, Lee VM, Trojanowski JQ, Ginsberg SD, Butovsky O, Zheng H, Cao W. Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease. J. Clin. Invest. 130:1912-1930, 2020.
- DeBerge M, Lantz C, Dehn S, Sullivan DP, van der Laan AM, Niessen HWM, Flanagan ME, Brat DJ, Feinstein MJ, Kaushal S, Wilsbacher LD, Thorp EB. Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair. J Exp Med. 218:e20200667, 2021.
- DeBerge M, Glinton K, Subramanian M, Wilsbacher LD, Rothlin CV, Tabas I, Thorp EB. Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction. J Clin Invest. 131:e139576, 2021.
- Roy E., Chiu G, Li S, Propson NE, Kanchi R., Wang B, Coarfa C., Zheng H, and Cao W. Concerted cellular responses to type I interferon propel memory impairment associated with amyloid β plaques. Immunity, 55: 879-894, 2022.
- Zhao P, Xu Y, Jiang L, Fan X, Li L, Li X, Arase H, Zhao Y, Cao W, Zheng H, Xu H, Tong Q, Zhang N, and An Z. A tetravalent TREM2 agonistic antibody with α TfR-mediated brain entry for the reduction of amyloid pathology in 5XFAD mice. Sci Transl Med, 14, eabq0095, 2022.
- Roy E and Cao W. Glial interference: impact of type I interferon in neurodegenerative diseases. Mol Neurodegener 17: 78, 2022.
- Roy ER, Li S, Saroukhani S. Wang Y, and Cao W. Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging. Mol Neurodegener, 19:48, 2024.
- Thorp EB, Filipp M, Dima M, Tan C, Feinstein M, Popko B, DeBerge M. CCR2+ monocytes promote white matter injury and cognitive dysfunction after myocardial infarction. Brain Behav Immun. 119:818-835, 2024.
Extramural Research Funding of the CACD
From the past 5 years
National Institute of Health
- Project Number: R01 AG074283 (PI: Cao)
Title: Antiviral response coupled with transposon derepression in Alzheimer’s disease and aging
Project/Proposal Start and End Date: (MM/YYYY): 08/15/2021 - 05/31/2026
Total Award Amount (including Indirect Costs): $3,245,100 - Project Number: R01 DK122708-03W1 (MPI: Ju; Cao)
Title: Elucidating the role of Chi3l1 in mediating astrocyte/microglia cross-talk and promoting neurodegeneration in AD
Project/Proposal Start and End Date: (MM/YYYY): 7/1/2022-8/31/2024
Total Award Amount (including Indirect Costs): $390,000 - Project Number: R01 HL154720-03S1 (MPI: Eltzschig; Cao)
Title: Hypoxia inducible factors in shaping neuroinflammation and Alzheimer's pathogenesis
Project/Proposal Start and End Date: (MM/YYYY): 7/1/2023-11/30/2024
Total Award Amount (including Indirect Costs): $390,000 - Project Number: RF1 AG057587 (MPI: Cao; Zheng)
Title: Interrogating the Interferon Pathway in Aging and Alzheimer's Disease
Project/Proposal Start and End Date: (MM/YYYY): 06/01/2018 – 08/31/2023
Total Award Amount (including Indirect Costs): $2,881,490
Joe and Dorothy Dorsett Brown Foundation
- Project Number: N/A (PI: Cao)
Title: Targeting Interferon-mediated Neuroinflammation to Restore Age-related Memory Deficits
Project/Proposal Start and End Date: (MM/YYYY): 12/11/19-12/31/23
Total Award Amount (including Indirect Costs): $111,000
Bright Focus Foundation
- Project Number: 1A2018377S (PI: Cao)
Title: Role of type I interferon in Alzheimer's Disease
Project/Proposal Start and End Date: (MM/YYYY): 7/1/2018-6/30/2021
Total Award Amount (including Indirect Costs): $300,000