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Publications of the CHGR

From the past 5 years with impact factors >10

  1. Y. Yang, L. Xu, C. Atkins, L. Kuhlman, J. Zhao, J.M. Jeong, Y. Wen, N. Moreno, K.H. Kim, Y. A. An, F. Wang, S. Bynon, V. Villani, B. Gao, F. Brombacher, R. Harris, H.K. Eltzschig, E. Jacobsen, C. Ju (2024). “Novel Il-4/HB-EGF-depdendent crosstalk between eosinophils and macrophages controls liver regeneration after ischemia and reperfusion injury”. GUT, doi:10.1136, PMID: 38724220.
  2. Feng D, Xiang X, Guan Y, Guillot A, Lu H, Chang C, He Y, Wang H, Pan H, C. Ju, Colgan SP, Tacke F, Wang XW, Kunos G, Gao B. (2023). “Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models”. Journal of Clinical Investigation, 133(15):e166954, PMID: 37338984.
  3. Y. Wen, C. Emontzpohl, L. Xu, C.L. Atkins, J.M. Jeong, Y. Yang, K. Kim, C. Wu, S. Akira, C. Ju (2023). “Interleukin-33 facilitates liver regeneration through serotonin-involved gut-liver axis”. Hepatology, 177 (5): 1580-1592.
  4. L. Xu, Y. Yang, J. Jiang, Y. Wen, J. Jeong, C. Emontzpohl, C.L. Atkins, K. Kim, E.A. Jacobsen, H. Wang, C. Ju (2023). “Eosinophils protect against acetaminophen-induced liver injury through cyclooxygenase-mediated IL-4/IL-13 production”. Hepatology, doi:10.1002/hep.32609, PMID: 35714036.
  5. L. Xu, Y. Yang, J.M. Jeong, C. Emontzpohl, C.L. Atkins, Z. Sun, K.L. Poulsen, D.R. Hall, J.S. Bynon, B. Gao, W.M. Lee, E.A. Jacobsen, H. Wang, C. Ju (2022). “Hepatic recruitment of eosinophils and their protective function during acute liver injury”. Journal of Hepatology, S0168-8278, PMID: 35259470.
  6. Y. Wang, Y. Yang, M. Wang, S. Wang, J. Jeong, L. Xu, Y. Wen, C. Emontzpohl, C.L. Atkins, K. Duong, N.F. Moreno, X. Yuan, D.R. Hall, W. Dar, D. Feng, B. Gao, Y. Xu, Z. Czigany, S. P. Colgan, J.S. Bynon, S. Akira, J.M. Brown, H.K. Eltzschig, E.A. Jacobsen, C. Ju (2021). “Eosinophils attenuate hepatic ischemia reperfusion injury in mice through ST2-dependent IL-13 production”. Science Translational Medicine, 13:eabb6576, PMID: 33536281.
  7. Y. Ait Ahmed, Y. Fu, R.M. Rodrigues, Y. He, Y. Guan, A. Guillot, R. Ren, D. Feng, J. Hidalgo, C. Ju, F. Lafdil, Gao B (2021). “Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners”. Cellular and Molecular Immunology, 18:2165-2176, PMID: 34282300.
  8. Z. Shan, L. Li, C.L. Atkins, M. Wang, Y. Wen, J. Jeong, N.F. Moreno, D. Feng, X. Gui, N. Zhang, C.G. Lee, J.A. Elias, W.M. Lee, B. Gao, F.W. Lam, Z. An, C. Ju (2021). “Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment”. eLife, 10:e68571, PMID: 34110284.
  9. C. Ju, M. Wang, E. Tak, B. Kim, C. Emontzpohl, Y. Yang, X. Yuan, H. Kutay, Y. Liang, D.R. Hall, W. Dar, J.S. Bynon, P. Carmeliet, K. Ghoshal, and H.K. Eltzschig (2021). “HIF-dependent induction of miR-122 enhances hepatic ischemia tolerance”. Journal of Clinical Investigation, 131:e140300, PMID: 33792566.
  10. Y. Wen, J. Lambrecht, C. Ju, F. Tacke (2021) “Hepatic macrophages in liver homeostasis and disease-diversity, plasticity and therapeutic opportunities”. Cell Mol Immunol, 18(1):45-56, PMID: 33041338.
  11. Y. Wen and C. Ju (2020) “Mer Proto-oncogene Tyrosine Kinase: A Novel Potential Target to Treat Nonalcoholic Steatohepatitis Fibrosis”. Hepatology, 72:772-774, PMID: 32171039.
  12. R.Y. Gao, M. Wang, Q. Liu, D. Feng, Y. Wen, Y. Xia, S.P. Colgan, H.K. Eltzschig and C.Ju (2020) “Hypoxia-Inducible Factor (HIF)-2a Reprograms Liver Macrophages to Protect Against Acute Liver Injury via the Production of Interleukin-6”. Hepatology, 71:2105-2117, PMID: 31529728.
  13. Zhao S, Lin Q, Xiong W, Li L, Straub L, Zhang D, Zhu Q, Sun X, Zhang Z, Funcke J, Li C, Chen S, Zhu Y, Jiang N, Li G, Xu Z, Wyler S, Wang M, Bai J, Han X, Kusminski C, Zhang Z, An Z, Elmquist Joel, Osborn O, Liu C, Scherer P. Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders. Science Translational Medicine, 2023, 15(723), eade8460.
  14. Liu H#, He Y#, Bai J#, Zhang C, Zhang F, Yang Y, Luo H, Yu M, Liu H, Tu L, Zhang N, Yin N, Han J, Yan Z, Scarcelli N, Conde K, Wang M, Bean J, Potts C, Wang C, Hu F, Liu F*, Xu Y*. Hypothalamic Grb10 suppresses obesity by enhancing leptin signaling. Nature Metabolism, 2023, 5(1): 147-164.
  15. Liu F, Cai Z, Yang Y, Plasko G, Zhao P, Wu X, Tang C, Li D, Li T, Hu S, Song L, YU S, Xu R, Luo H, Fan L, Wang E, Xiao Z, Ji Y, Zeng R, Li R, Bai J, Zhou Z, Liu F, Zhang J. The adipocyte-enriched secretory protein tetranectin exacerbates type 2 diabetes by inhibiting insulin secretion from β cells. Science Advance, 2022, 8(38): eabq1799.
  16. Bai J* and Liu F*. Nuclear cGAS: sequestration and beyond. Protein & Cell, 2022, 13: 90-101.
  17. He S, Ryu J, Liu J, Luo H, Lv Y, Langlais P, Wen J, Dong F, Sun Z, Xia W, Lynch J, Duggirala R, Nicholson B, Zang M, Shi Y, Zhang F, Liu F, Bai J*, Dong LQ*. LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance. J Clin Invest, 2021, 131(24): e148545.
  18. Zhou H*, Peng X, Hu J, Wang L, Luo H, Zhang J, Zhang Y, Li G, Ji Y, Zhang J, Bai J, Liu M, Zhou Z, Liu F*. DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN- duction. Nat Commun, 2021, 12 (1):326. PMID: 33436607.
  19. Cox AR, Masschelin PM, Saha PK, Felix JB, Sharp R, Lian Z, Xia Y, Chernis N, Bader DA, Kim KH, Li X, Yoshino J, Li X, Li G, Sun Z, Wu H, Coarfa C, Moore DD, Klein S, Sun K, Hartig SM. The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice. Cell Metab. 2022 Dec 6;34(12):1932-1946.e7.
  20. Pastore N, Huynh T, Herz NJ, Calcagni' A, Klisch TJ, Brunetti L, Kim KH, De Giorgi M, Hurley A, Carissimo A, Mutarelli M, Aleksieva N, D'Orsi L, Lagor WR, Moore DD, Settembre C, Finegold MJ, Forbes SJ, Ballabio A. TFEB regulates murine liver cell fate during development and regeneration. Nat Commun. 2020 May 18;11(1):2461.
  21. Treviño LS, Dong J, Kaushal A, Katz TA, Jangid RK, Robertson MJ, Grimm SL, Ambati CSR, Putluri V, Cox AR, Kim KH, May TD, Gallo MR, Moore DD, Hartig SM, Foulds CE, Putluri N, Coarfa C, Walker CL. Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood. Nat Commun. 2020 May 8;11(1):2316.
  22. Dong B, Zhou Y, Wang W, Scott J, Kim K, Sun Z, Guo Q, Lu Y, Gonzales NM, Wu H, Hartig SM, York RB, Yang F, Moore DD. Vitamin D Receptor Activation in Liver Macrophages Ameliorates Hepatic Inflammation, Steatosis, and Insulin Resistance in Mice. Hepatology. 2020 May;71(5):1559-1574.
  23. Zhou Y, Dong B, Kim KH, Choi S, Sun Z, Wu N, Wu Y, Scott J, Moore DD. Vitamin D Receptor Activation in Liver Macrophages Protects Against Hepatic Endoplasmic Reticulum Stress in Mice. Hepatology. 2020 Apr;71(4):1453-1466.
  24. Choi S, Dong B, Lin CJ, Heo MJ, Kim KH, Sun Z, Wagner M, Putluri N, Suh JM, Wang MC, Moore DD. Methyl-Sensing Nuclear Receptor Liver Receptor Homolog-1 Regulates Mitochondrial Function in Mouse Hepatocytes. Hepatology. 2020 Mar;71(3):1055-1069.
  25. Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, Nuotio-Antar AM. Metabolic dysregulation in the Atp7b(-/-) Wilson's disease mouse model. Proc Natl Acad Sci USA. 2020 Jan 28;117(4):2076-2083.
  26. Czopik A, Yuan X, Evans SE, Eltzschig HK. Targeting the Hypoxia-Adenosine Link for Controlling Excessive Inflammation. Anesthesiology. 2021 Jul 1;135(1):15-17.

Extramural Research Funding of the CHGR

For the past 5 years

Federal Grants

  1. Project Number: R01DK121330 (PI: Ju)
    Title: Role of Eosinophils in Hepatic Ischemia Reperfusion Injury
    Project/Proposal Start and End Date (MM/YYYY): 06/2019-03/2027
    Total Award Amount (including Indirect Costs): $3,399,720
  2. Project Number: R01AA030735 (PI: Ju)
    Title: Role of neutrophil-specific NOX2 in alcohol-induced liver injury
    Project/Proposal Start and End Date (MM/YYYY): 06/2023-05/2028
    Total Award Amount (including Indirect Costs): $2,161,935
  3. Project Number: R01DK122708 (PI: Ju)
    Title: Role of chitinase-3-like-1 (Chi3l1) in acetaminophen-induced liver injury
    Project/Proposal Start and End Date (MM/YYYY): 09/2019-08/2024
    Total Award Amount (including Indirect Costs): $1,982,710
  4. Project Number: R01DK122796 (MPI: Ju, Eltzschig)
    Title: Targeting miR-122 for the treatment of perioperative liver injury
    Project/Proposal Start and End Date (MM/YYYY): 05/2020-03/2024
    Total Award Amount (including Indirect Costs): $1,829,330
  5. Project Number: R01DK109574 (MPI: Ju, Eltzschig)
    Title: Hypoxia-Inducible Factors in Acetaminophen-Induced Injury
    Project/Proposal Start and End Date (MM/YYYY): 10/2016-06/2021
    Total Award Amount (including Indirect Costs): $3,616,387
  6. Project Number: R01DK126656 (PI: Kim)
    Title: The Role of Hepatokine ORM2 in Adipose Tissue Inflammation
    Project/Proposal Start and End Date (MM/YYYY): 07/2021-04/2026
    Total Award Amount (including Indirect Costs): $1,950,000
  7. Project Number: DK136848: NIH/R01 (PI: Bai)
    Title: Innate Immunity in NASH
    Project/Proposal Start and End Date (MM/YYYY): 07/2023-04/2027
    Total Award Amount (including Indirect Costs): $1,895,928
  8. Project Number: DOD/USAMRAA award HT9425-23-1-0094 (PI: Czopik)
    Title: Role of hypoxia-induced miR-29 in T cell-mediated inflammation in IBD
    Project/Proposal Start and End Date (MM/YYYY): 04/2023-03/2025
    Total Award Amount (including Indirect Costs): $312,000
  9. Project Number: K01 DK146248 (PI: Heo)
    Title: Role of Kynurenine-AhR Signals in Cholestatic Liver Injury
    Project/Proposal Start and End Date (MM/YYYY): 03/2026-01/2029
    Total Award Amount (including Indirect Costs): $462,996

Non-Federal Grants

  1. Project Number: CPRIT (PI: Ju)
    Title: Targeting CHI3L1 as a novel therapy for hepatocellular carcinoma
    Project/Proposal Start and End Date (MM/YYYY): 04/2024-03/2027
    Total Award Amount (including Indirect Costs): $1,049,392
  2. Project Number: TRC4-175154 (PI: Ju)
    Title: Investigation of the therapeutic potential of eosinophils to attenuate trauma and combat casualty-related liver injury
    Project/Proposal Start and End Date (MM/YYYY): 04/2024-07/2025
    Total Award Amount (including Indirect Costs): $492,789
  3. Project Number: P30 DK056338 (PI: Heo)
    Title: Kynurenine Pathway Mechanism in Cholestatic Liver Injury
    Project/Proposal Start and End Date (MM/YYYY): 06/2025-05/2026
    Total Award Amount (including Indirect Costs): $50,000
  4. Project Number: TRC4-2025-PTRA-0317 (PI: Kim and Ju)
    Title: Harnessing Arachidonate Metabolome in Traumatic Liver Injury
    Project/Proposal Start and End Date (MM/YYYY): 10/2025-06/2027
    Total Award Amount (including Indirect Costs): $500,000

Gifts in kind to the IBD research group

  1. Paula Mischer Foundation, $110,000, 2023
  2. Jerold B. Katz Foundation, $500,000, 2024