Office of Technology Management
University Center Tower (UCT)
7000 Fannin Street, Suite 720
Houston, Texas 77030
Phone: (+1) 713-500-3369
Fax: (+1) 713-500-0331
R-spondins (RSPOs) are secreted proteins with critical roles in cancer development through binding to LGRs and RNF43/ZNRF3 and potentiating Wnt signaling. Various RSPO mutants were discovered that bind to LGRs but no longer function in Wnt signaling. Fc fusion protein of the RSPO mutants, so called RSPO peptibodies, were conjugated with cytotoxic drugs and the resulting conjugates were able to inhibit the growth of cancer cells expressing LGR4, LGR5 and/or LGR6 in vitro and in vivo without major adverse effect. Background RSPOs and LGR4-6 (leucine-rich repeat containing, G protein...
Magnetic Resonance Imaging (MRI) is the most commonly used imaging modality for diagnosis and surveillance of various neurosurgical conditions, while patients usually need to undergo a rigorous screening process prior to MRI examination to ensure the implants they have are MR safe and assure patient safety. Researchers at UTHealth have developed a new pipeline to identify implantable device MRI compatibility using mobile phone quality images, which outperforms the other currently available methods, and has the potential to become a safety tool for radiologists to efficiently coordinate th...
Researchers from UTHealth have developed a novel oncolytic viral therapy, oHSV-shPKR, which can inhibit tumor cells’ antiviral PKR activity, and increase oncolytic virus infection and replication in both oncolytic viral-resistant and sensitive cancer cells. This novel oHSV-shPKR therapy can significantly increase the anti-tumor immune response against cancer and show a striking anti-tumor effect in vivo and has the potential to become the promising oncolytic viral therapy for cancer treatment. Background Oncolytic viruses (OVs), such as oHSV, are an emerging treatment strategy f...