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Identifying and characterizing genes whose perturbation leads to intracranial aneurysms (IA) and/or vascular endothelial cell dysfunction

The proposed invention involves identification and characterization of molecular targets for treating intracranial aneurysms. A focus is endothelial podosomes regulated by the transmembrane receptor protein THSD1. THSD1 also regulates autophagy processes that contribute to aneurysm formation as well as positively regulates TGFβ signaling, which may ameliorate IA disease. Technology Overview The technology is a novel therapeutic approach to treat intracranial aneurysms via elucidation and characterization of several genes involved in endothelial podosome formation, which has been shown to...

Directional and Scalable (DISC) Electrode Array

­Overview. A directional and scalable (DISC) electrode array has been developed and tested to provide improved performance while overcoming limitations seen in conventional neural sensors. The array design proposed here is an improvement on the state-of-the-art electroencephalogram (sEEG) by enabling the recording of spatially distinct local field potentials (LFP). This is achieved by radially positioning of electrodes around the array using advanced manufacturing techniques. The device demonstrates superior performance in terms of signal-to-noise (SNR), directional sensitivity, and deco...

Synthetic Antifungal Peptides

­Novel antifungal compositions that inhibit fungal growth which have both medical and non-medical utility and applications Inventors at the University of Texas Health Science Center at Houston have developed a series of novel peptide compounds to inhibit fungal growth. The peptides are based on the bacteriocin EntV, which is secreted by Enterococcus faecalis. Studies in their lab have shown that the peptide is effective against Candida albicans infection not only in a C. elegans model but also in a mouse model of systemic infection and a rat model of venous catheter infection. Importantly...

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