Current Studies
| # | Project Title | PI | Type of Research | Brief Description |
|---|---|---|---|---|
| 1 | Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial) | Yafen Liang, MD | RCT | A randomized controlled trial to explore the possibility of reducing the incidence of acute kidney injury in patients undergoing cardiac surgery with cardiopulmonary bypass machine support. |
| 2 | Comparison of Early Proton pump inhibitor initiation versus Usual care on Acute Kidney Injury (CEPU-AKI) in hemorrhagic shock patients | Yafen Liang, MD | RCT | A randomized controlled trial to explore the possibility of reducing the incidence of acute kidney injury in trauma patients with hemorrhagic shock. |
| 3 | Impact of HIV on Perioperative Organ Injury and Surgical Outcomes: A Comparative Study Using the National Inpatient Sample Database | Yafen Liang, MD | Retrospective Cohort Study | An analysis of the National Inpatient Sample database in order to assess the impact of perioperative organ injury in patients living with HIV. |
| 4 | Comparison of Incidence and Impact of Perioperative Organ Injury (POI) on Surgical Outcomes Before and During the Pandemic: An Analysis Using the National Inpatient Sample (NIS) Database | Yafen Liang, MD | Retrospective Cohort Study | An analysis of the National Inpatient Sample database in order to assess the impact of perioperative organ injury during the COVID-19 pandemic. |
| 5 | Perioperative Organ Injury and Postoperative Outcomes in the National Inpatient Sample | Yafen Liang, MD | Retrospective Cohort Study | An analysis of the National Inpatient Sample to assess the impact of perioperative organ injury in the US. |
Grants
| GRANT# | Title | PI | Major Goals |
|---|---|---|---|
| R01 EB19403 (Status:Acti ve) $2,573,021 |
Secondary Use of EMRs for Surgical Complication Surveillance | Hongfang Liu; Curt Storlie | The proposed project aims to further enhance and disseminate the digital platform for post-surgical complication surveillance. |
| 1OT2OD03 2701 |
Patient-Focused Collaborative Repository Uniting Standards (CHoRUS) for Equitable AI - Tool Development and Optimization Module | Hongfang Liu (Site MPI) | To generate AI- ready data for predictive modeling. |
| R01HG 12748 | Learning Precision Medicine for Rare Diseases | Hongfang Liu | Advance rare disease diagnosis with knowledge- |
| (Status: Active) $2,860,103 |
Empowered by Knowledge- driven Data Mining | Empowered by Knowledge- driven Data Mining driven data mining approaches. | |
| RR230020 (Status: Active) $6,000,000 |
Real-world Data for Precision Oncology through Data Science and Informatics Excellence in Research (WONDER) | Hongfang Liu | Advance rare disease diagnosis with knowledge- driven data mining approaches |
| R01 LM011934- 08 (Status:Acti ve) $3,013,662 |
Semi-structured information Retrieval in Clinical Text for Cohort Identification | Liu, Hongfang/Hersh, William | Make full use of clinical text in retrieving patients from the EMR. A layered language model for searching clinical text is introduced, addressing the need for both fine- grained information and big-picture contextual information |
| R01AG 72799-01 (Status:Acti ve) $954,000 |
Facilitate observational studies of Alzheimer’s disease and Alzheimer’s disease-related dementias using ontology and natural language processing | Xu, Hua/Liu, Hongfang/Tao, Cui | This project aims to develop informatics solutions for EHR- based ADRD research. |
| R01AT 09457-05 (Status:Acti ve) $399,745 |
A Translational Informatics Framework to Mine Efficacy and Safety of Dietary Supplements | Zhang, Rui | Develop a framework for mining efficacy for safety of dietary supplements. |
| U24TR004 432 (Status:Acti ve) $397,500 |
Catalyzing and Harmonizing Operational Innovation for Recruitment (CHOIR) | Liu, Hongfang | This is a submission for informatics innovations for clinical trials. Mayo’s subcontract is to add natural language processing capabilities to the solution stack. |