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Funding and Publications

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Publications of the CPCM

From the past five years with impact factors greater than 10

  1. Yuan X, Ruan W, Bobrow B, Carmeliet P, Eltzschig HK. Targeting hypoxiainducible factors: therapeutic opportunities and challenges. Nat Rev Drug Discov. 2024 Mar;23(3):175-200. doi: 10.1038/s41573-023-00848-6. Epub 2023 Dec 20. PMID: 38123660.
  2. Liang Y, Ruan W, Jiang Y, Smalling R, Yuan X, Eltzschig HK. Interplay of hypoxia-inducible factors and oxygen therapy in cardiovascular medicine. Nat Rev Cardiol. 2023 Jun 12;. doi: 10.1038/s41569-023-00886-y. [Epub ahead of print] Review. PubMed PMID: 37308571.
  3. Faraoni EY, Singh K, Chandra V, Le Roux O, Dai Y, Sahin I, O'Brien BJ, Strickland LN, Li L, Vucic E, Warner AN, Pruski M, Clark T, Van Buren G, Thosani NC, Bynon JS, Wray CJ, Bar-Sagi D, Poulsen KL, Vornik LA, Savage MI, Sei S, Mohammed A, Zhao Z, Brown PH, Mills T, Eltzschig HK, McAllister F, Bailey-Lundberg JM. CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer. Cancer Res. 2023 Apr 4;83(7):1111-1127. doi: 10.1158/0008-5472.CAN-22-2553. PubMed PMID: 36720042; PubMed Central PMCID: PMC10071819.
  4. Ruan W, Eltzschig HK, Yuan X. Hypoxia-stabilized RIPK1 promotes cell death.Nat Cell Biol. 2023 Jul;25(7):921-922. doi: 10.1038/s41556-023-01176-y. PubMed PMID: 37400499.
  5. Dery KJ, Kojima H, Kageyama S, Kadono K, Hirao H, Cheng B, Zhai Y, Farmer DG, Kaldas FM, Yuan X, Eltzschig HK, Kupiec-Weglinski JW. Alternative splicing of CEACAM1 by hypoxia-inducible factorischemia in mice and humans. Sci Transl Med. 2023 Aug 2;15(707):eadf2059. doi: 10.1126/scitranslmed.adf2059. Epub 2023 Aug 2. PubMed PMID: 37531413.
  6. Wang R, Lee JH, Kim J, Xiong F, Hasani LA, Shi Y, Simpson EN, Zhu X, Chen YT, Shivshankar P, Krakowiak J, Wang Y, Gilbert DM, Yuan X, Eltzschig HK, Li W. SARS-CoV-2 restructures host chromatin architecture. Nat Microbiol. 2023 Apr;8(4):679-694. doi: 10.1038/s41564-023-01344-8. Epub 2023 Mar 23. PubMed PMID: 36959507; PubMed Central PMCID: PMC10116496.
  7. Li J, Conrad C, Mills TW, Berg NK, Kim B, Ruan W, Lee JW, Zhang X, Yuan X, Eltzschig HK. PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling. J Exp Med. 2021 Jun 7;218(6). doi: 10.1084/jem.20210008. PubMed PMID: 33891683; PubMed Central PMCID: PMC8077173.
  8. Wang Y, Yang Y, Wang M, Wang S, Jeong JM, Xu L, Wen Y, Emontzpohl C, Atkins CL, Duong K, Moreno NF, Yuan X, Hall DR, Dar W, Feng D, Gao B, Xu Y, Czigany Z, Colgan SP, Bynon JS, Akira S, Brown JM, Eltzschig HK, Jacobsen EA and Ju C. Eosinophils attenuate hepatic ischemia-reperfusion injury in mice through ST2-dependent IL-13 production. Sci Transl Med. 2021;13.
  9. Ruan W, Yuan X and Eltzschig H. Circadian Mechanisms in Medicine. N Engl J Med. 2021;384:e76.
  10. Ruan W, Yuan X and Eltzschig HK. Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021;20:287-307.
  11. Ju C, Wang M, Tak E, Kim B, Emontzpohl C, Yang Y, Yuan X, Kutay H, Liang Y, Hall DR, Dar WA, Bynon JS, Carmeliet P, Ghoshal K and Eltzschig HK. Hypoxiainducible factor- -dependent induction of miR122 enhances hepatic ischemia tolerance. J Clin Invest. 2021;131.
  12. Lee TJ, Yuan X, Kerr K, Yoo JY, Kim DH, Kaur B and Eltzschig HK. Strategies to Modulate MicroRNA Functions for the Treatment of Cancer or Organ Injury. Pharmacol Rev. 2020;72:639-667.

Extramural Research Funding of the CPCM

From the past five years

National Institute of Health

  1. Project Number: R01HL169519 (MPI: Eltzschig, Yuan)
    Title: Functional Role of HIF PHDs in ARDS
    Project/Proposal Start and End Date (MM/YYYY): 08/01/2023 – 08/31/2027
    Total Award Amount (including Indirect Costs): $3,421,710
  2. Project Number: R01HL165748 (MPI: Eltzschig, Tsai, Muehlschelgel)
    Title: Circadian Rhythm as a Therapeutic Target for Perioperative Cardioprotection
    Project/Proposal Start and End Date (MM/YYYY): 05/11/2023 – 04/30/2027
    Total Award Amount (including Indirect Costs): $3,616,387
  3. Project Number: R01HL155950 (PI: Yuan)
    Title: Targeting Myeloid Dependent MicroRNAs in Acute Respiratory Distress Syndrome
    Project/Proposal Start and End Date (MM/YYYY): 02/01/2022 – 01/31/2027
    Total Award Amount (including Indirect Costs): $1,950,000
  4. Project Number: R01HL154720 (PI: Eltzschig)
    Title: MicroRNA miR-147 Dampens Alveolar Epithelial Inflammation during ARDS
    Project/Proposal Start and End Date (MM/YYYY): 12/15/2020 – 11/30/2024
    Total Award Amount (including Indirect Costs): $1,795,867
  5. Project Number: 1R01DK122796 (MPI: Ju, Eltzschig)
    Title: Targeting microRNA miR-122 for the Treatment of Perioperative Liver Injury
    Project/Proposal Start and End Date (MM/YYYY): 05/11/2020 – 03/31/2024
    Total Award Amount (including Indirect Costs): $1,829,330
  6. Project Number: R01DK109574 (MPI: Ju, Eltzschig)
    Title: Hypoxia-Inducible Factors in Acetaminophen-Induced Injury
    Project/Proposal Start and End Date (MM/YYYY): 10/01/2016 – 06/30/2021
    Total Award Amount (including Indirect Costs): $3,616,387
  7. Project Number: R01HL133900 (PI: Eltzschig)
    Title: MicroRNA Shuttling during Acute Respiratory Distress
    Project/Proposal Start and End Date (MM/YYYY): 04/01/2017 – 03/31/2022
    Total Award Amount (including Indirect Costs): $1,540,000

Department of Defense

  1. Project Number: W81XWH2110032 (PI: Eltzschig)
    Title: A randomized, phase 2 clinical trial of HIF-activator Vadadustat for prevention or treatment of ARDS in hospitalized COVID-19 patients
    Project/Proposal Start and End Date (MM/YYYY): 01/01/21 – 06/30/2024
    Total Award Amount (including Indirect Costs): $5,162,372

Mentored Research Grants

  1. Project Number: 19CDA34660279 (PI: Yuan; Mentor: Eltzschig)
    Title: The role of miR-147 in acute respiratory distress syndrome
    Sponsor: American Heart Association
    Project/Proposal Start and End Date (MM/YYYY): 04/01/2019-12/15/2020
    Total Award Amount (including Indirect Costs): $231,000
  2. Project Number: 622265 (PI: Yuan; Mentor: Eltzschig)
    Title: The role of miR-147 in acute respiratory distress syndrome
    Sponsor: American Lung Association
    Project/Proposal Start and End Date (MM/YYYY): 07/01/2019-06/30/2021
    Total Award Amount (including Indirect Costs): $100,000
  3. Project Number: N/A (PI: Yuan; Mentor: Eltzschig)
    Title: microRNA-147 Controls the Lipopolysaccharide-Induced Inflammatory Response in Macrophages
    Sponsor: Parker B. Francis Foundation
    Project/Proposal Start and End Date (MM/YYYY): 07/01/2020-06/30/2023
    Total Award Amount (including Indirect Costs): $225,000
  4. IARS Mentored Research Award (PI: Ruan; Mentor: Eltzschig)
    Title: Circadian cardioprotection: BMAL1/HIF2A complex and co-target amphiregulin
    Sponsor: International Anesthesia Research Society
    Project/Proposal Start and End Date (MM/YYYY): 08/01/2022 - 08/30/2024
    Total Award Amount (including Indirect Costs): $175,000
  5. Project Number: HT94252310094 (PI: Czopik; Mentor: Eltzschig)
    Title: Role of hypoxia-induced miR-29 in T cell-mediated inflammation in intestinal inflammation
    Sponsor: Department of Defense PRMP Medical Discovery Award
    Project/Proposal Start and End Date (MM/YYYY): 04/01/2023 - 03/31/2025
    Total Award Amount (including Indirect Costs): $312,000
  6. AHA Postdoctoral Fellowship (PI: Ma; Mentor: Eltzschig) Neutrophils-derived miR-223-3p attenuates myocardial ischemia-reperfusion injury by targeting RhoB
    Sponsor: American Heart Association
    Project/Proposal Start and End Date (MM/YYYY): 01/01/2024 – 12/31/2025
    Total Award Amount (including Indirect Costs): $164,973
  7. Pilot Grant Award (PI: Tran; Mentor: Yuan) MicroRNA in Neonatal Hypoxic Respiratory Failure
    Sponsor: Department of Pediatrics, McGovern Medical School, UTHealth Houston
    Project/Proposal Start and End Date (MM/YYYY): 01/01/2024 – 12/31/2025
    Total Award Amount (including Indirect Costs): $15,000
  8. T32 Training Grant (PI: Eltzschig & Ju; Awardee: Paul Potnuru)
    Title: Research Training of Anesthesiology Physician-Scientists
    Sponsor: NIH Project/Proposal Start and End Date (MM/YYYY): 09/01/2024 – 6/30/2025
    Total Award Amount (including Indirect Costs): $85,795.20
  9. T32 Training Grant (PI: Eltzschig & Ju; Awardee: Thu Thien Tran)
    Title: Research Training of Anesthesiology Physician-Scientists
    Sponsor: NIH Project/Proposal Start and End Date (MM/YYYY): 07/01/2024 – 6/30/2025
    Total Award Amount (including Indirect Costs): $94,569.12
  10. T32 Training Grant (PI: Eltzschig & Ju; Awardee: Kevin Huang)
    Title: Research Training of Anesthesiology Physician-Scientists
    Sponsor: NIH
    Project/Proposal Start and End Date (MM/YYYY): 07/01/2024 – 6/30/2025
    Total Award Amount (including Indirect Costs): $94,569.12

Industry-sponsored research

  1. Project Number: NA (PI: Eltzschig, Bobrow)
    Title: Vadadustat for the prevention and treatment of acute respiratory distress syndrome (ARDS) in hospitalized patients with Coronavirus Disease 2019 (COVID-19)
    Project/Proposal Start and End Date: (MM/YYYY): 07/13/2020 – 12/31/2023
    Total Award Amount (including Indirect Costs): $1,680,746